Jan 1, 2014

Vitamin D and high blood pressure: causal association or epiphenomenon?

European Journal of Epidemiology
Setor Kwadzo KunutsorHassan Khan


High plasma levels of vitamin D are associated with a reduced risk of high blood pressure, but whether this association is causal remains to be ascertained. We performed a meta-analysis of randomized clinical trials, to examine the effect of vitamin D supplementation on both systolic blood pressure (SBP) and diastolic blood pressure (DBP) and supplemented these results with a Mendelian randomization analysis to investigate the causal relationship between vitamin D status (25-hydroxyvitamin D [25(OH)D]) and BP. Pooled random effects meta-analysis of weighted mean differences across 16 trials of vitamin D supplementation showed a non-significant reduction in SBP (-0.94, 95% CI -2.98, 1.10 mmHg) and DBP (-0.52, 95% CI -1.18, 0.14 mmHg), with evidence of heterogeneity (I(2) = 67.9%, P < 0.001) and publication bias (P = 0.02) among trials of SBP. There was a significant reduction in DBP (-1.31, 95% CI -2.28, -0.34 mmHg, P = 0.01) in participants with pre-existing cardiometabolic disease. Variants at three published loci (GC, DHCR7, CYP2R1, and CYP24A1) for 25(OH)D, were not significantly associated with BP, but rs6013897 in CYP24A1 gene region had nominally significant associations with both SBP and DBP (P < 0.05). Evidence from the...Continue Reading

Mentioned in this Paper

Diastolic Blood Pressure Measurement
Mendelian Randomization Analysis
Meta-Analysis (Publications)
Systolic Blood Pressure Measurement
Diastolic Blood Pressure
Clinical Trials, Randomized
Vitamin D Deficiency
Vitamin D

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