Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis

Sleep Medicine
Cindy Lee P NeighborsMacario Camacho

Abstract

Several studies have reported an association between 25-hydroxyvitamin D (25(OH)D) levels and obstructive sleep apnea (OSA) patients. The objective of the current study was to perform a systematic review and meta-analysis of these studies and report the findings. Authors searched for studies (through January 1, 2017) reporting 25(OH)D serum levels in OSA patients. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was followed. Fourteen studies with 4937 subjects met inclusion criteria. There were 1513 controls and 3424 OSA patients. The 25(OH)D serum levels for controls and mild OSA patients were 28.16 ± 9.39 ng/mL (95% CI 27.64, 28.68) and 27.41 ± 9.42 ng/mL (95% CI 26.87, 27.95), respectively. The 25(OH)D serum levels for controls and moderate OSA patients were 28.21 ± 9.38 ng/mL (95% CI 27.70, 28.72) and 25.48 ± 10.34 ng/mL (95% CI 24.68, 26.28), respectively. The 25(OH)D serum levels for controls and severe OSA patients were 28.32 ± 9.65 ng/mL (95% CI 27.80, 28.84) and 21.88 ± 10.24 ng/mL (95% CI 21.08, 22.68), respectively. Using random effects modeling, the 25(OH)D serum levels were decreased for patients with OSA when compared to control groups (mean differences were -2.7% for mild...Continue Reading

Citations

Sep 12, 2018·Expert Review of Respiratory Medicine·Macario CamachoClete A Kushida
Mar 13, 2019·International Journal of Environmental Research and Public Health·Janine GronewoldDirk M Hermann
Jun 28, 2019·JAMA Otolaryngology-- Head & Neck Surgery·Madeline J L RaveslootNico de Vries
Jan 31, 2020·Critical Reviews in Food Science and Nutrition·Luigi BarreaUNKNOWN E.O.L.O. Group
Mar 28, 2020·Psychiatry Investigation·Sun-Young KimYoung-Chul Shin
Jul 11, 2020·Sleep & Breathing = Schlaf & Atmung·Izolde BouloukakiSophia Schiza
May 23, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Danyan MaChangqin Liu
Jul 17, 2020·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Baha Al-ShawwaDavid G Ingram
Oct 8, 2020·Journal of Endocrinological Investigation·M PellegriniS Bo
May 1, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Lisa B MatlenGalit Levi Dunietz

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