Vitamin D and placental-decidual function

Journal of the Society for Gynecologic Investigation
Katie N EvansMartin Hewison

Abstract

The active form of vitamin D (1,25-dihydroxyvitamin D(3), 1,25[OH](2)D(3)) has well-established effects on bone metabolism and mineral homeostasis. However, recently it has become clear that 1,25(OH)(2)D(3) has potent antiproliferative and immunomodulatory actions that are not immediately linked to its role as a skeletal regulator. Both the nuclear receptor for 1,25(OH)(2)D(3) (vitamin D receptor, VDR) and the vitamin D-activating enzyme 1alpha-hydroxylase are expressed in a wide variety of nonclassic tissues, highlighting the potential for local autocrine-paracrine responses rather than traditional endocrine effects. Prominent among the tissues that express 1alpha-hydroxylase is the placenta-decidua, and this has raised important questions concerning the potential role of locally generated 1,25(OH)(2)D(3) as a modulator of fetal-placental development and function. When bound to the VDR, 1,25(OH)(2)D(3) regulates key target genes associated with implantation, such as HOXA10, whereas the potent immunosuppressive effects of 1,25(OH)(2)D(3) suggest a role in implantation tolerance. These observations are further supported by data from our group showing increased expression of 1alpha-hydroxylase and VDR in first-trimester trophobla...Continue Reading

References

May 1, 1992·Journal of Cellular Biochemistry·K Kragballe
Feb 1, 1989·Cellular Immunology·F MerinoA Durantez
Jan 1, 1988·Reproduction, Nutrition, Development·J N BulmerA Ritson
Jan 1, 1984·Annual Review of Nutrition·H L Henry, A W Norman
Jan 1, 1981·Endocrine Reviews·T K GrayG E Lester
Sep 30, 1994·Annals of the New York Academy of Sciences·J N Bulmer
Jul 1, 1996·The Journal of Endocrinology·D R ShamleyR Buffenstein
Feb 1, 1996·Journal of Reproductive Immunology·M J MontesE García-Olivares
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R HausslerP W Jurutka
Oct 28, 1998·Physiological Reviews·G JonesH F DeLuca
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·D ZehnderP M Stewart
Oct 3, 2000·Journal of Molecular Endocrinology·M HewisonP M Stewart
Apr 13, 2001·Seminars in Reproductive Medicine·G S Daftary, H S Taylor
Jun 1, 2001·The Journal of Nutrition·L E Johnson, H F DeLuca
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·D K PandaD Goltzman
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S GregoriL Adorini
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BoonstraA O'Garra
Nov 14, 2001·Reviews in Endocrine & Metabolic Disorders·M HewisonJ S Adams
Dec 1, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H F Deluca, M T Cantorna
Mar 20, 2002·Current Drug Targets·G J C M van den Bemd, G T G Chang
Mar 27, 2002·Endocrine-related Cancer·K W Colston, C Mørk Hansen
Apr 3, 2002·Trends in Molecular Medicine·Chantal Mathieu, Luciano Adorini
Apr 12, 2002·Immunology Letters·Ramon KanenoAurélio Borelli
Jun 19, 2002·American Journal of Reproductive Immunology : AJRI·Michael PlevyakSurendra Sharma
Jul 11, 2002·The American Journal of Pathology·Daniel ZehnderMartin Hewison
Aug 22, 2002·International Immunopharmacology·Luciano Adorini
Nov 20, 2002·Transplantation·Bryan N BeckerHector DeLuca
Dec 6, 2002·Cancer Metastasis Reviews·Candace S JohnsonDonald L Trump
Jan 10, 2003·Journal of Cellular Biochemistry·Julia B Zella, Hector F DeLuca
Jan 10, 2003·Journal of Cellular Biochemistry·Evelyne Van EttenChantal Mathieu
Feb 13, 2003·Toxicology·Olivier Thellin, Ernst Heinen
Mar 15, 2003·Molecular Endocrinology·Amelia L M Sutton, Paul N MacDonald
May 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Martin HewisonRonjon Chakraverty

❮ Previous
Next ❯

Citations

Mar 21, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Adrian F GombartH Phillip Koeffler
Jul 3, 2010·The British Journal of Nutrition·Elina Hyppönen, Barbara J Boucher
Aug 19, 2011·The Proceedings of the Nutrition Society·Martin Hewison
Aug 17, 2012·Nutrition Research Reviews·Hanna OlaussonAnn Prentice
Feb 18, 2012·Journal of Human Hypertension·C K H YuK H Nicolaides
Aug 24, 2012·Human Reproduction·B RudickK Bendikson
Jan 19, 2012·The Pediatric Infectious Disease Journal·Julia L FinkelsteinWafaie W Fawzi
Apr 21, 2010·Obstetrical & Gynecological Survey·Lisa M Bodnar, Hyagriv N Simhan
Nov 21, 2008·Nutrition Reviews·Robyn M LucasRuth Morley
Jul 22, 2010·Nutrition Reviews·Daphna K Dror, Lindsay H Allen
Nov 4, 2011·Reproductive Biology and Endocrinology : RB&E·Magdalena Grundmann, Frauke von Versen-Höynck
May 19, 2012·Endocrine Reviews·Clifford J RosenChristopher S Kovacs
Mar 1, 2010·Nutrients·Anne-Louise PonsonbyJane Halliday
May 6, 2011·The American Journal of Clinical Nutrition·Helle Margrete MeltzerMargareta Haugen
Mar 4, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·Baohui ZhaoKathleen E Bethin
Apr 16, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Laura BergadàXavier Matias-Guiu
Jan 27, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Euclides AvilaFernando Larrea
May 24, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·I V ReevesK N Washington
Nov 8, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ian MarshallAnna Petrova
Jul 15, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Resul ArisoySemih Tugrul
Jun 13, 2015·Journal of Endocrinological Investigation·S Triunfo, A Lanzone
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Helen L Henry
Nov 13, 2008·Paediatric and Perinatal Epidemiology·Lisa M Bodnar, Hyagriv N Simhan
Jul 7, 2012·Paediatric and Perinatal Epidemiology·Andrew Thorne-Lyman, Wafaie W Fawzi
Apr 28, 2011·Clinical Endocrinology·James E HaddowJun Lu
May 24, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Samira RajaeiAmir Hassan Zarnani
Apr 19, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ana M Fernández-AlonsoFaustino R Pérez-López
Jan 15, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shu-Qin WeiWilliam D Fraser
Feb 27, 2015·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·T P H NguyenP Murthi
Apr 17, 2015·Reproductive Biology and Endocrinology : RB&E·Anne Marie Z JukicDonna D Baird
Apr 22, 2015·Archives of Gynecology and Obstetrics·Rimpi Singla
Dec 6, 2014·Archives of Gynecology and Obstetrics·Rimpi SinglaRakesh Kochhar
May 23, 2015·BioMed Research International·Anna PleskačováKateřina Kaňková
May 23, 2015·BioMed Research International·Francesca ColoneseOnofrio Triolo
Jun 15, 2016·Journal of Obstetrics and Gynaecology of India·Taru GuptaPushpa Bhatia
May 26, 2016·BMC Pregnancy and Childbirth·Ghadeer K Al-ShaikhHazem Al-Mandeel
Jun 2, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gulenay Gencosmanoglu TurkmenDilek Uygur
Nov 6, 2013·BMC Medical Genomics·Alvin T KhoKelan G Tantisira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.