Vitamin D and risk of cognitive decline in elderly persons.

Archives of Internal Medicine
David J LlewellynDavid Melzer

Abstract

To our knowledge, no prospective study has examined the association between vitamin D and cognitive decline or dementia. We determined whether low levels of serum 25-hydroxyvitamin D (25[OH]D) were associated with an increased risk of substantial cognitive decline in the InCHIANTI population-based study conducted in Italy between 1998 and 2006 with follow-up assessments every 3 years. A total of 858 adults 65 years or older completed interviews, cognitive assessments, and medical examinations and provided blood samples. Cognitive decline was assessed using the Mini-Mental State Examination (MMSE), and substantial decline was defined as 3 or more points. The Trail-Making Tests A and B were also used, and substantial decline was defined as the worst 10% of the distribution of decline or as discontinued testing. The multivariate adjusted relative risk (95% confidence interval [CI]) of substantial cognitive decline on the MMSE in participants who were severely serum 25(OH)D deficient (levels <25 nmol/L) in comparison with those with sufficient levels of 25(OH)D (>/=75 nmol/L) was 1.60 (95% CI, 1.19-2.00). Multivariate adjusted random-effects models demonstrated that the scores of participants who were severely 25(OH)D deficient dec...Continue Reading

References

Jul 22, 1995·Lancet·R P van der WielenW A van Staveren
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Mar 15, 2002·Trends in Endocrinology and Metabolism : TEM·Emmanuel GarcionDidier Wion
Oct 27, 2004·Age and Ageing·Jugdeep K DhesiTheresa J Allain
Mar 8, 2005·Neurobiology of Aging·Antonio CherubiniLuigi Ferrucci
May 12, 2005·JAMA : the Journal of the American Medical Association·Heike A Bischoff-FerrariBess Dawson-Hughes
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Dario MaggioLuigi Ferrucci
Dec 20, 2005·Lancet·Cleusa P FerriUNKNOWN Alzheimer's Disease International
Dec 2, 2006·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Consuelo H WilkinsJohn C Morris
Dec 21, 2006·JAMA : the Journal of the American Medical Association·Kassandra L MungerAlberto Ascherio
Jan 19, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Harold L Newmark, Jonathan Newmark
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Sep 12, 2007·Archives of Internal Medicine·Philippe Autier, Sara Gandini
Nov 2, 2007·Journal of Elder Abuse & Neglect·Koko AungCarmel Bitondo Dyer
Dec 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joyce C McCann, Bruce N Ames
Mar 19, 2008·Annals of Internal Medicine·Brenda L PlassmanRobert B Wallace
Apr 19, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R PrzybelskiN Binkley
May 20, 2008·Age and Ageing·Iain A LangDavid Melzer
May 27, 2008·Dementia and Geriatric Cognitive Disorders·C OudshoornT J M van der Cammen
Jun 6, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Robert P Heaney
Jun 27, 2008·Molecular Aspects of Medicine·Jennifer S Buell, Bess Dawson-Hughes
Dec 17, 2008·Journal of Geriatric Psychiatry and Neurology·David J LlewellynIain A Lang
Apr 21, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jennifer S BuellKatherine L Tucker
May 23, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·David M LeeUNKNOWN EMAS study group

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Citations

Apr 15, 2014·Clinical Interventions in Aging·Mathias Schlögl, Michael F Holick
Mar 29, 2014·The Journal of Nutrition, Health & Aging·B BartaliJ H Kang
Nov 2, 2013·The Proceedings of the Nutrition Society·Emmeline Ayers, Joe Verghese
Jan 18, 2014·AJNR. American Journal of Neuroradiology·J M PragerY G Wu
Jul 18, 2014·Annual Review of Nutrition·Natalie J GrovesThomas H J Burne
Feb 27, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Babak HooshmandMiia Kivipelto
Aug 28, 2014·European Journal of Clinical Nutrition·P Barberger-Gateau
Oct 1, 2014·Proceedings of the National Academy of Sciences of the United States of America·Caitlin S LatimerNada M Porter
Oct 13, 2010·Journal of Neuroengineering and Rehabilitation·Cedric AnnweilerOlivier Beauchet
Jun 26, 2012·European Journal of Nutrition·Elske M Brouwer-BrolsmaLisette C P G M de Groot
Sep 26, 2012·Neurology·Cynthia BalionParminder Raina
Mar 29, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yelena SlininUNKNOWN Study of Osteoporotic Fractures Research Group
Apr 17, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Cédric AnnweilerOlivier Beauchet
Oct 20, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H JohanssonD Mellström
Jan 21, 2012·Dementia and Geriatric Cognitive Disorders·C AnnweilerO Beauchet
Dec 20, 2012·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Duygu Gezen-AkSelma Yilmazer
Feb 3, 2016·Physiology & Behavior·Natalie J Groves, Thomas H J Burne
Nov 1, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E M MowryE Waubant
Mar 1, 2016·Neurobiology of Aging·Alexandra M KueiderMadhav Thambisetty
Aug 14, 2012·Journal of Critical Care·Alessandro MorandiL B Ware
Dec 27, 2011·Pharmacology & Therapeutics·Haythum O TayebFrank I Tarazi
Jan 24, 2012·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·G MuscogiuriA Giaccari
Sep 4, 2012·European Journal of Internal Medicine·Cédric Annweiler, Olivier Beauchet
Sep 14, 2011·Neuroscience Letters·Donald J LehmannA David Smith
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Lauren R HarmsJohn J McGrath
May 31, 2011·Autoimmunity Reviews·Evelyn PeelenJan Damoiseaux
Jun 15, 2011·Molecular and Cellular Endocrinology·James P KesbyJohn J McGrath
May 24, 2011·Seminars in Oncology·Anne H BlaesTufia Haddad
Apr 1, 2011·Journal of the American Medical Directors Association·Dallas P SeitzPaula A Rochon
Dec 29, 2015·Journal of Clinical and Experimental Neuropsychology·Jacqueline A Pettersen
Jan 22, 2013·Journal of Neuropathology and Experimental Neurology·Joost SmoldersInge Huitinga
Dec 24, 2010·Journal of Gerontological Nursing·Jonathan PlantonBarbara J Edlund
Mar 14, 2016·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Uazman AlamRayaz A Malik
May 21, 2013·Annals of the New York Academy of Sciences·Sylvia ChristakosDaniel D Bikle
Jan 23, 2013·Neuropathology and Applied Neurobiology·G C DeLucaG C Ebers
Jan 14, 2011·Journal of the American Geriatrics Society·Cédric AnnweilerOlivier Beauchet

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