Vitamin D and Uterine Fibroids-Review of the Literature and Novel Concepts

International Journal of Molecular Sciences
Michał CiebieraGrzegorz Jakiel

Abstract

This article provides a detailed review of current knowledge on the role of vitamin D and its receptor in the biology and management of uterine fibroids (UFs). Authors present ideas for future steps in this area. A literature search was conducted in PubMed using the following key words: "uterine fibroid" and "vitamin D". The results of the available studies, published in English from January 2002 up to April 2018, have been discussed. Vitamin D is a group of steroid compounds with a powerful impact on many parts of the human body. This vitamin is believed to regulate cell proliferation and differentiation, inhibit angiogenesis, and stimulate apoptosis. Nowadays, hypovitaminosis D is believed to be a major risk factor in the development of UFs. In many studies vitamin D appears to be a powerful factor against UFs, resulting in inhibition of tumor cell division and a significant reduction in its size, however, the exact role of this compound and its receptor in the pathophysiology of UFs is not fully understood. According to available studies, vitamin D and its analogs seem to be promising, effective, and low-cost compounds in the management of UFs and their clinical symptoms, and the anti-tumor activities of vitamin D play an im...Continue Reading

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Citations

Jan 12, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Michał CiebieraGrzegorz Jakiel
Jun 5, 2019·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Tomasz ŁozińskiMichał Ciebiera
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Aug 28, 2019·Menopause : the Journal of the North American Menopause Society·UNKNOWN The North American Menopause Society (NAMS)
May 20, 2020·Journal of Clinical Medicine·Michał CiebieraAyman Al-Hendy
Aug 6, 2020·International Journal of Molecular Sciences·Michał CiebieraAyman Al-Hendy
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Oct 28, 2020·Reproductive Sciences·Michał CiebieraAyman Al-Hendy
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May 1, 2021·Nutrients·Michał CiebieraMohamed Ali
Aug 20, 2019·Journal of Infection and Public Health·Jianyan XuanYuhua Zheng

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Methods Mentioned

BETA
nuclear translocation
contraception

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