PMID: 11899952Mar 20, 2002Paper

Vitamin D and vitamin D analogs in cancer treatment

Current Drug Targets
G J C M van den Bemd, G T G Chang

Abstract

The secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is a key player in the regulation of bone mineralization and calcium homeostasis. In addition, 1,25-(OH)2D3 has antiproliferative and prodifferentiation effects on various cells in vitro and in vivo. The growth-inhibitory properties of 1,25-(OH)2D3 could be harnessed in the treatment of cancer. However, its use as an anti-cancer drug is limited because of the calcemic effects of pharmacological doses. In an attempt to dissociate the antiproliferative and calcemic effects, numerous vitamin D3 analogs were developed. The mechanisms by which 1,25-(OH)2D3 and 1,25-(OH)2D3 analogs exert their growth-inhibitory effects are not clear but include effects on cell differentiation, apoptosis, cell cycle regulation, metastases, and angiogenesis. In the current review aspects involved in the tumor suppressive activity of 1,25-(OH)2D3 and 1,25-(OH)2D3 analogs will be addressed. The use of vitamin D3 compounds, alone or in combination with other drugs, in cancer treatment and the potential drawbacks will also be discussed.

Citations

Dec 20, 2005·Diseases of the Colon and Rectum·Ramu Raju, Marcia Cruz-Correa
Mar 18, 2004·Molecular and Cellular Endocrinology·Martin HewisonJohn S Adams
Aug 23, 2002·Journal of Internal Medicine·William B Grant, Cedric F Garland
Jul 3, 2010·Journal of the American College of Nutrition·Roula BarakéKatherine Gray-Donald
May 23, 2014·Applied Microbiology and Biotechnology·Rita Bernhardt, Vlada B Urlacher
Mar 10, 2009·Annals of Epidemiology·William B Grant, Sharif B Mohr
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Jul 2, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Tina GisselPeter Vestergaard
Jan 9, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Alina Carmen PorojnicuJohan Moan
Feb 26, 2005·Clinical Endocrinology·Leif Mosekilde
Dec 13, 2006·Journal of Cosmetic Dermatology·W B GrantC F Garland
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Reinhold Vieth
Dec 7, 2006·International Journal of Cancer. Journal International Du Cancer·William B Grant
Dec 14, 2011·Chemistry : a European Journal·Ramón FragaAntonio Mouriño
Oct 7, 2004·Brain Research. Developmental Brain Research·Pauline KoDarryl Eyles
Jul 22, 2004·Experimental Cell Research·Michael Danilenko, George P Studzinski
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·M H Pourgholami, D L Morris
May 20, 2016·Dermato-endocrinology·Alan B Fleischer, Sarah E Fleischer
Mar 21, 2006·Progress in Biophysics and Molecular Biology·William B Grant
Aug 6, 2005·The Journal of Steroid Biochemistry and Molecular Biology·Kelly TownsendMartin Hewison
Jul 16, 2014·Bioorganic & Medicinal Chemistry·Alba Hernández-MartínVlada B Urlacher
Apr 10, 2015·Pharmaceutical Biology·Marco GiammancoGaetano Leto
Jul 15, 2015·Journal of Clinical Orthopaedics and Trauma·Raju VaishyaJabed Jahangir
May 1, 2010·Cancer Biology & Therapy·Radharani MarikChristopher B Umbricht
May 4, 2007·Nutrition and Cancer·Ashley Serene Plant, Glenn Tisman
Jul 3, 2004·Nutrition and Cancer·William B Grant, Cedric F Garland
Jun 29, 2004·Journal of the Society for Gynecologic Investigation·Katie N EvansMartin Hewison
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kelly TownsendMartin Hewison

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Angiogenesis Inhibitors to Treat Cancer

Cancer treatments including angiogenesis inhibitors prevent tumor cells from receiving nutrients and oxygen. Here is the latest research on angiogenesis inhibitors for the treatment of cancer.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.