Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension

Current Protein & Peptide Science
Lin LinYunlun Li

Abstract

Vitamin D, as a natural medicine, is known to regulate calcium and phosphate homeostasis. But abundant research has shown that vitamin D also plays a regulatory role in autoimmunity, inflammation, angiogenesis and vascular cell activity. Since the vitamin D receptor (VDR) is widely distributed in vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin D and VDR in hypertension has received extensive attention. Hypertension is a disease with high incidence and high cardiovascular risk. In recent years, both clinical trials and animal experiments have shown that vitamin D plays a regulatory role in decreasing blood pressure (BP) through inhibiting renin- angiotensin-aldosterone system activity, modulating function of vascular wall and reducing vascular oxidative stress. A growing body of data suggest that vitamin D deficiency is associated with increased cardiovascular disease risk in hypertension, even short-term vitamin D deficiency may directly raise BP and promote target organ damage. Due to the high correlation between vitamin D and hypertension, vitamin D supplementation therapy may be a new insight in the treatment of hypertension. The aim of this review will explore the mechanisms ...Continue Reading

Citations

Sep 11, 2020·Clinical and Experimental Hypertension : CHE·Zizheng SuoJinghui Dong
Nov 19, 2020·Clinical and Experimental Hypertension : CHE·Fatih Yılmaz, Hasan Sözel
Feb 13, 2021·Biomedicines·Andrei Mihai SurduGabriel Cismaru
Aug 28, 2021·Nutrients·Maja CvekVesna Boraska Perica

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