Vitamin D as a follicular marker of human oocyte quality and a serum marker of in vitro fertilization outcome

Journal of Assisted Reproduction and Genetics
Przemysław CiepielaRafał Kurzawa

Abstract

This study investigated the relationship between the vitamin D [25(OH)D] level in individual follicles and oocyte developmental competence. A prospective cohort study in a private infertility center. Infertile women (N = 198) scheduled for intracytoplasmic sperm injection (ICSI) and a single embryo transfer (SET) provided serum samples and 322 follicular fluid (FF) specimens, each from a single follicle on the day of oocyte retrieval. FFs corresponding to successfully fertilized oocytes (following ICSI) contained significantly lower 25(OH)D level compared with those that were not fertilized (28.4 vs. 34.0 ng/ml, P = 0.001). Top quality embryos on the third day after fertilization, when compared to other available embryos, developed from oocytes collected from follicles containing significantly lower 25(OH)D levels (24.56 vs. 29.59 ng/ml, P = 0.007). Positive hCG, clinical pregnancy, and live birth rates were achieved from embryos derived from oocytes that grew in FF with significantly lower 25(OH)D levels than in follicles not associated with subsequent pregnancy. The concentration of 25(OH)D in FF in women with negative hCG was 32.23 ± 20.21 ng/ml, positive hCG 23.62 ± 6.09 ng/ml, clinical pregnancy 23.13 ± 6.09 ng/ml, and liv...Continue Reading

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Citations

Oct 29, 2018·Journal of Assisted Reproduction and Genetics·Mauro Cozzolino
Oct 31, 2018·Journal of Assisted Reproduction and Genetics·Przemysław Ciepiela
May 15, 2019·Nutrients·Anna Bednarska-CzerwińskaAnd Andrzej Tukiendorf
Feb 15, 2020·Systems Biology in Reproductive Medicine·Patrycja SkowrońskaKrzysztof Łukaszuk
Jun 21, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alaa ShehadehArieh Moussaieff
Jul 20, 2019·Reproductive Biology and Endocrinology : RB&E·Xuemei LiuYanling Wan
Dec 8, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Daniela MenichiniFabio Facchinetti
May 29, 2021·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Patrycja SkowrońskaKrzysztof Łukaszuk
Aug 10, 2021·Archives of Gynecology and Obstetrics·Kahindo P MuyayaloAi-Hua Liao
Oct 12, 2021·Systems Biology in Reproductive Medicine·Mark JainOlga Panina

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Methods Mentioned

BETA
Assay
pregnancy test

Software Mentioned

Statistica

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