Vitamin D as an anti-microbial and anti-inflammatory therapy for Cystic Fibrosis

Paediatric Respiratory Reviews
K HerscovitchLarry C Lands

Abstract

Cystic fibrosis (CF) is characterized by chronic infection and inflammation in the airways that lead to progressive lung damage and early death. Current anti-inflammatory therapies are limited by extensive adverse effects or insufficient efficacy. There is a large body of studies indicating beneficial anti-microbial and anti-inflammatory properties of vitamin D. Since most patients with CF present with vitamin D deficiency, and serum vitamin D levels demonstrate a positive correlation with lung function and negative correlation with airway inflammation and infection, correcting vitamin D deficiency may be an attractive therapeutic strategy in CF. The function of vitamin D is intricately tied to its metabolism, which may be impaired at multiple steps in patients with CF, with a potential to limit the efficacy of vitamin D supplementation. It is likely that the aforementioned beneficial properties of vitamin D require supplementation with doses of vitamin D markedly higher than those recommended to maintain proper bone function. This review will illustrate the potential for supplementation with vitamin D or its metabolites to modulate inflammation and improve defence against chronic infection in CF lung, as well as appropriate vi...Continue Reading

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Citations

Jan 15, 2014·Paediatric Respiratory Reviews·Dominic A Fitzgerald
Apr 10, 2016·Acta Paediatrica·Konstantinos Douros
Jan 29, 2017·The Journal of Steroid Biochemistry and Molecular Biology·Kristina M DiFrancoGill Diamond
Aug 23, 2017·World Journal of Clinical Pediatrics·Maria MoustakiKonstantinos Douros
May 17, 2019·Expert Review of Respiratory Medicine·Carla ColomboGianfranco Alicandro
Feb 22, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Adela Chirita-EmandiSyed Faisal Ahmed
Sep 13, 2018·International Journal of Molecular Sciences·Mayte MedranoJose A Perez-Simon

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