Abstract
Vitamin D binding protein (DBP) is a polymorphic serum protein with a predominant role in a spectrum of biological activities. Chronic renal failure is characterized by deficient vitamin D metabolism. The present study investigates the impact of DBP polymorphism on the need for vitamin D in hemodialysis patients. This was a retrospective study. This study included hemodialysis patients from the Renal Unit of Ghent University Hospital (Ghent, Belgium) and the Algemeen Stedelijk Ziekenhuis Geraardsbergen Hospital (Geraardsbergen, Belgium). One hundred and ninety-one hemodialysis patients and 211 healthy subjects were recruited from the hemodialysis database. The DBP phenotypes were determined by polyacrylamide gel electrophoresis. Serum DBP, parathyroid hormone, 25-hydroxyvitamin D(3), 1,25-dihydroxyvitamin D(3), calcium, albumin, and phosphate were measured. Information regarding the intake of vitamin D analogues was collected. The phenotypic distributions of DBP were in agreement with Hardy-Weinberg equilibrium. Comparing allele frequencies of the two groups, there was an increased proportion of the DBP 2 allele in hemodialysis patients (P < .05). The median serum DBP concentration was lowest in the DBP 2-2 group. The need for ...Continue Reading
References
Jan 1, 1992·Nephron·A St JohnR L Prince
Sep 1, 1988·Electrophoresis·J Constans, H Cleve
Apr 1, 1986·Human Genetics·M I Kamboh, R E Ferrell
Dec 1, 1981·The Journal of Clinical Endocrinology and Metabolism·M KawakamiD S Goodman
Sep 1, 1993·Human Genetics·J Arnaud, J Constans
Mar 3, 1999·Cell·A NykjaerT E Willnow
Mar 3, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·A J Brown
Sep 21, 2000·Trends in Endocrinology and Metabolism : TEM·P White, N Cooke
Nov 10, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Schömig, E Ritz
Dec 21, 2002·Clinical Biochemistry·Diana R CliveGordon D MacFarlane
Mar 27, 2004·Blood Purification·Katsuhiko YonemuraAkira Hishida
May 4, 2005·Calcified Tissue International·A L LauridsenE Nexo
Aug 4, 2005·Seminars in Dialysis·Dennis L Andress
Nov 29, 2005·Bone·Youri E C TaesJean-Marc Kaufman
May 16, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Marijn SpeeckaertYouri E C Taes
May 20, 2006·Clinical Chemistry·Ursula MeierAxel M Gressner
Apr 13, 2007·Clinical Biochemistry·Olav GressnerFrank Lammert
Citations
Sep 4, 2015·Seminars in Dialysis·Michelle R Denburg, Ishir Bhan
Oct 13, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Ying GaoZhonghua Chen
Jun 29, 2012·The Journal of Nutrition·Siobhan MuldowneyMairead Kiely
Jul 4, 2020·Proteomics. Clinical Applications·Tianlin HeVera Jankowski