Vitamin D-Binding Protein Enhances Epithelial Ovarian Cancer Progression by Regulating the Insulin-like Growth Factor-1/Akt Pathway and Vitamin D Receptor Transcription

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Yu-Fang HuangCheng-Yang Chou

Abstract

Purpose: Malignant ascites of epithelial ovarian cancer (EOC) helps identify prognostic biomarkers or mechanisms of tumor progression. Vitamin D-binding protein (DBP) was revealed to be upregulated in EOC ascites in our previous proteomic study. Here, we examined the role of DBP in EOC.Experimental Design: We analyzed ascites, serum, and tissue samples of patients with newly diagnosed EOC to determine the prognostic effects of DBP. We verified DBP function using orthotopic animal models and DBP regulation in ovarian cancer cell lines.Results: Elevated ascitic DBP was significantly associated with poor response to chemotherapy, short progression-free interval, increased cancer progression, and death. Ascitic DBP overexpression was an independent unfavorable biomarker for progression-free survival; DBP overexpression in cancerous tissue was significantly related to chemoresistance. In vivo and in vitro investigations demonstrated an important role for DBP in ovarian cancer progression. Orthotopic model mice inoculated with DBP knockdown ovarian cancer cells displayed a significant reduction in tumor formation, malignant cell number, ascitic DBP levels, invasiveness, and metastasis, and increased survival compared with controls. I...Continue Reading

References

Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S P XieK W Colston
Aug 2, 2003·Breast Cancer Research and Treatment·Srilatha SwamiDavid Feldman
Feb 15, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A A Ayantunde, S L Parsons
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson
Feb 24, 2009·Annals of Epidemiology·Elizabeth R Bertone-Johnson
Oct 28, 2010·Cancer Research·Alison M MondulDemetrius Albanes
Apr 25, 2012·Cell Biochemistry and Function·Rene F Chun
May 5, 2012·The European Respiratory Journal·Alice M TurnerBabu Naidu
May 25, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alison M MondulDemetrius Albanes
Jun 1, 2012·Frontiers in Endocrinology·Laura VuoloAnnamaria Colao
Feb 8, 2013·International Journal of Cancer. Journal International Du Cancer·Yu-Ming YehLu-Hai Wang
Feb 22, 2013·Nature Reviews. Cancer·Emma KippsStan B Kaye
Oct 8, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Rene F ChunMartin Hewison
Nov 12, 2013·International Journal of Cancer. Journal International Du Cancer·Alison M MondulDemetrius Albanes
Nov 26, 2013·Endocrine-related Cancer·Yu-Fang HuangCheng-Yang Chou
Jul 19, 2014·PloS One·Gabriella M AnicDemetrius Albanes
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Aug 18, 2017·International Journal of Cancer. Journal International Du Cancer·Yi-Hui WuCheng-Yang Chou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.