Vitamin D-Binding Protein in Health and Chronic Kidney Disease

Seminars in Dialysis
Michelle R Denburg, Ishir Bhan

Abstract

Vitamin D-binding protein (DBP) is a multifunctional protein that has attracted increasing interest in recent years, largely because of its potential role in modulating the activity of vitamin D. Nearly all circulating vitamin D (~85-90%) circulates bound to DBP, with a smaller proportion bound to albumin, leaving <5% circulating freely. DBP may also play roles beyond vitamin D binding, with potential roles in the immune system and elsewhere. Numerous polymorphisms of DBP exist around the world, and recent studies have identified relevance of different DBP phenotypes in determining DBP concentration and vitamin D affinity. This review focuses on the known roles of DBP in health and kidney disease, and current views on the relevance of DBP polymorphisms.

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Citations

Nov 18, 2019·Current Osteoporosis Reports·Dorey A Glenn, Michelle R Denburg
Jan 20, 2016·Current Opinion in Nephrology and Hypertension·Andrew L Lundquist, Sagar U Nigwekar
Jan 23, 2019·The Journal of Clinical Endocrinology and Metabolism·Joseph LunyeraJulia J Scialla
Aug 23, 2020·International Journal of Molecular Sciences·Jarosław NuszkiewiczKarolina Szewczyk-Golec

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