Vitamin D-binding protein-loaded PLGA nanoparticles suppress Alzheimer's disease-related pathology in 5XFAD mice

Nanomedicine : Nanotechnology, Biology, and Medicine
Seong Gak JeonMinho Moon

Abstract

The aggregation and accumulation of amyloid beta (Aβ) peptide is believed to be the primary cause of Alzheimer's disease (AD) pathogenesis. Vitamin D-binding protein (DBP) can attenuate Aβ aggregation and accumulation. A biocompatible polymer poly (D,L-lactic acid-co-glycolic acid) (PLGA) can be loaded with therapeutic agents and control the rate of their release. In the present study, a PLGA-based drug delivery system was used to examine the therapeutic effects of DBP-PLGA nanoparticles in Aβ-overexpressing (5XFAD) mice. DBP was loaded into PLGA nanoparticles and the characteristics of the DBP-PLGA nanoparticles were analyzed. Using a thioflavin-T assay, we observed that DBP-PLGA nanoparticles significantly inhibited Aβ aggregation in vitro. In addition, we found that intravenous injection of DBP-PLGA nanoparticles significantly attenuated the Aβ accumulation, neuroinflammation, neuronal loss and cognitive dysfunction in the 5XFAD mice. Collectively, our results suggest that DBP-PLGA nanoparticles could be a promising therapeutic candidate for the treatment of AD.

Citations

Jun 5, 2019·Journal of Biomedical Materials Research. Part a·Ting LiJianhua Wang
Mar 3, 2020·Frontiers in Bioengineering and Biotechnology·Divesha EssaViness Pillay
Oct 28, 2020·Analytical Methods : Advancing Methods and Applications·Nabodita SinhaAshwani Kumar Thakur
Dec 31, 2019·Nanomedicine : Nanotechnology, Biology, and Medicine·Gopal PatelUttam Chand Banerjee
Jan 28, 2021·International Journal of Molecular Sciences·Samo Ribarič
Apr 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thuy Trang NguyenVan Giau Vo
May 18, 2021·Frontiers in Bioengineering and Biotechnology·Nazeer Hussain KhanXin-Ying Ji
Jul 3, 2021·Materials·Hernán CortésGerardo Leyva-Gómez
Sep 4, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Thuy Trang NguyenGiau Van Vo
Aug 31, 2021·Journal of Alzheimer's Disease : JAD·Alex HandyUNKNOWN AddNeuroMed, and the GERAD1 Consortium
Oct 23, 2020·Current Pharmaceutical Design·Ankit TandonRajnish K Chaturvedi

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