Vitamin D concentration and its association with past, current and future depression in older men: The Health In Men Study

Maturitas
Osvaldo P AlmeidaLeon Flicker

Abstract

Vitamin D deficiency has been associated with depression in later life, but it remains unclear whether this association is truly causal. Observational study examining the retrospective, cross-sectional and prospective associations between vitamin D concentration and depressed mood in a community-derived sample of 3105 older men living in metropolitan Perth, Western Australia. We measured the plasma concentration of 25-hydroxyvitamin D using standard procedures. Past depression was ascertained by direct questioning and through the use of administrative health data linkage. A geriatric depression scale score equal or greater 7/15 established the presence of current depression. Incident depression was established by a patient health questionnaire (PHQ-9) score ≥ 10 or by administrative health data linkage during the 6-year follow up (range 0.1-10.9 years). Vitamin D concentration <50 nmol/L was associated with greater odds of current (OR=1.65, 95% CI=1.13, 2.42) but not past depression (OR=1.15, 95% CI=0.83, 1.58). Of the 2740 men with no past or current history of depression, 81 developed clinically significant symptoms during follow up. The adjusted hazard ratio of incident depression for men with plasma vitamin D <50 nmol/L was...Continue Reading

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Citations

May 31, 2016·Journal of Evaluation in Clinical Practice·Avivit Golan-CohenYacov Fogelman
Jun 28, 2016·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Theresa Katharina SchäferThomas Meyer
Jul 29, 2016·European Journal of Nutrition·Caroline CollinEmmanuelle Kesse-Guyot
Oct 18, 2016·Journal of Affective Disorders·Gordon B ParkerRebecca K Graham
Jul 29, 2018·European Journal of Endocrinology·Liset E M ElstgeestMarjolein Visser
May 17, 2019·CNS Drugs·Gleicilaine A S CassebAna Lúcia S Rodrigues
Oct 10, 2018·European Journal of Endocrinology·Liset E M ElstgeestMarjolein Visser
Oct 8, 2020·The Journal of Nutrition·Neha SahasrabudheNatalia Palacios
Sep 29, 2020·Sleep Medicine Reviews·Laura M Huiberts, Karin C H J Smolders

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