Vitamin D deficiencies among tuberculosis patients in Africa: A systematic review

Nutrition
Tibebeselassie Seyoum KeflieHans Konrad Biesalski

Abstract

The aim of this study was to explore the existence of vitamin D deficiency (VDD) in tuberculosis (TB) patients living in Africa and to identify its predictor variables. PRISMA guidelines and checklists were used. The sources of the data were Medline/PubMed, Web of Science, Scopus, and Google Scholar databases. We identified 23 articles, of which 15 reported the status of vitamin D in TB with TB. The definition of serum vitamin D status was summarized as severe, deficient, and insufficient when the concentration of 25-hydroxyvitamin (OH)-D ≤25, ≤50, and ≤75 nmol/L, respectively. The reports showed that up to 88.9% and 96.3% of patients with TB tested by radioimmunoassay had VDD and vitamin D insufficiency, respectively. Statistically significant variables such as lack of sun exposure, inadequate dietary intake, season, clothing, comorbidities, low body mass index, age, skin pigmentation, use of antiretroviral therapy and anti-TB drugs, and socioeconomic status were identified as the main predictor variables of vitamin D status. VDD and vitamin D insufficiency were highly prevalent in TB patients in Africa. Further case-control studies are warranted to clarify the cause-effect relationship between vitamin D and TB and thereby, de...Continue Reading

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Citations

Jul 1, 2016·Annals of the New York Academy of Sciences·Hans K Biesalski
Jun 21, 2017·International Journal of Surgery·Liang TangShi-Qing Feng
Jul 8, 2017·Tropical Medicine & International Health : TM & IH·Hoang van TongChristian G Meyer

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