Vitamin D deficiency aggravates ischemic acute kidney injury in rats

Physiological Reports
Ana Carolina de BragançaL Andrade

Abstract

Vitamin D deficiency (VDD) increases the risk of death in hospitalized patients. Renal ischemia/reperfusion injury (IRI) induces acute kidney injury (AKI), which activates cell cycle inhibitors, including p21, a cyclin-dependent kinase inhibitor and genomic target of 25-hydroxyvitamin D, which is in turn a potent immunomodulator with antiproliferative effects. In this study, we assess the impact of VDD in renal IRI. Wistar rats were divided into groups, each evaluated for 30 days: control (receiving a standard diet); VDD (receiving a vitamin D-free diet); IRI (receiving a standard diet and subjected to 45-min bilateral renal ischemia on day 28); and VDD + IRI (receiving a vitamin D-free diet and subjected to 45-min bilateral renal ischemia on day 28). At 48 h after IRI, animals were euthanized; blood, urine, and kidney tissue samples were collected. Compared with IRI rats, VDD + IRI rats showed a more severe decrease in glomerular filtration rate, greater urinary protein excretion, a higher kidney/body weight ratio and lower renal aquaporin 2 expression, as well as greater morphological damage, characterized by increased interstitial area and tubular necrosis. Our results suggest that the severity of tubular damage in IRI may b...Continue Reading

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Citations

Nov 1, 2015·International Journal of Cardiology·Huibo WangPing Zeng
Jul 3, 2016·Physiological Reports·Ana C de BragançaDavid P Basile
Jul 12, 2019·PLoS Neglected Tropical Diseases·Daniela FerreiraDaniele Canale
Jul 11, 2019·Archives of Physiology and Biochemistry·Raghad Khalid Al-IshaqDietrich Büsselberg
Aug 22, 2018·International Journal of Environmental Research and Public Health·Pedro Henrique Franca GoisAntonio Carlos Seguro
Aug 4, 2020·Experimental Biology and Medicine·Chandrashekar AnnamalaiPragasam Viswanathan
May 11, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yi-Fang MengPan Xiao
Jul 4, 2018·Clinical and Experimental Nephrology·Magda HamzawyNivin Sharawy
Oct 30, 2018·Frontiers in Medicine·Ana Carolina de BragançaRildo Aparecido Volpini
Mar 9, 2021·Analytical Cellular Pathology (Amsterdam)·Chandrashekar AnnamalaiPragasam Viswanathan
Apr 20, 2021·Frontiers in Medicine·Michele Santiago Dos SantosAna Carolina de Bragança
Mar 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ning LiuJuan Kong

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
light microscopy
PCR

Software Mentioned

Pro Plus
Image

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