Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?

Journal of Clinical Research in Pediatric Endocrinology
Olcay EvliyaoğluMine Kucur

Abstract

Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients. This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects. The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3). Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

Citations

Aug 25, 2016·Eating and Weight Disorders : EWD·Massimiliano CaprioAndrea Fabbri
Mar 16, 2017·Thyroid : Official Journal of the American Thyroid Association·Shiqian Hu, Margaret P Rayman
Sep 13, 2017·International Journal of Molecular Sciences·Dohee Kim
Jan 17, 2017·Reviews in Endocrine & Metabolic Disorders·Immacolata Cristina NettorePaolo Emidio Macchia
Mar 21, 2020·BMC Endocrine Disorders·Salma AhiNaser Hatami
Sep 17, 2020·Nutrients·Inês Henriques VieiraIsabel Paiva
May 21, 2020·Nutrients·Chiara MelePaolo Marzullo
Apr 28, 2017·Journal of Cosmetic Dermatology·Mehmet Unal, Gulsum Gonulalan
Jun 9, 2020·Minerva pediatrica·Silvia SavastioGianni Bona
Aug 25, 2021·BMC Endocrine Disorders·Sorour TaheriniyaGholamreza Askari
Aug 28, 2021·Nutrients·Maja CvekVesna Boraska Perica

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