Vitamin D deficiency and its association with fatigue and quality of life in advanced cancer patients under palliative care: A cross-sectional study

Palliative Medicine
Montserrat Martínez-AlonsoMaria Nabal

Abstract

A normal vitamin D status is required for bones and muscles to maintain their function and structure, but it also contributes to the functional integrity of other multiple physiologic systems in the body. To assess the relationship of Vitamin D deficiency with health-related quality-of-life issues, fatigue, and physical functioning in advanced cancer patients. This is a cross-sectional study. Adults under palliative care, having a locally advanced or metastatic or inoperable solid cancer. Among 30 patients in palliative care with advanced solid cancer, 90% were vitamin D deficient. Serum Vitamin D concentration was positively correlated with patient-reported absence of fatigue (s = 0.49), and physical and functional well-being (s = 0.44 and s = 0.41, respectively, p < 0.01). Fatigue was the symptom with the highest median impact on their lives and was the only one associated with serum vitamin D (p = 0.031), with lower fatigue in patients with vitamin D concentrations in the third tertile. There was no evidence of a direct association between health-related quality of life and vitamin D status. The 90% frequency of advanced cancer patients with vitamin D deficiency, together with the positive correlation of vitamin D status wit...Continue Reading

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Citations

Apr 17, 2016·BMJ Supportive & Palliative Care·Linda Björkhem-Bergman, Peter Bergman
Oct 21, 2016·Journal of the American Geriatrics Society·Chia-Ter ChaoUNKNOWN COhort of GEriatric Nephrology in National Taiwan University Hospital (COGENT) Study Group
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Sep 25, 2019·The Journal of International Medical Research·Claudia VollbrachtIris Friesecke
Mar 1, 2019·Scientific Reports·Alexandra HavdahlGeorge Davey Smith
Aug 11, 2019·Breast Cancer Research and Treatment·Angel ArnaoutMark Clemons

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