Vitamin D deficiency and its association with fatigue and quality of life in multiple sclerosis patients.

The EPMA Journal
Yesim BeckmannSule Uysal Duman

Abstract

Vitamin D deficiency is associated with the incidence and prevalence of a variety of neurologic disorders, including multiple sclerosis. However, available studies to date have not provided convincing evidence that vitamin D treatment improves fatigue and life quality in patients with multiple sclerosis. To assess the relationship of vitamin D deficiency with health-related quality-of-life issues and fatigue in multiple sclerosis patients. Vitamin D3 levels were measured in 149 multiple sclerosis patients. In patients with lower than 30 ng/mL levels, vitamin D was administered. Fatigue and health-related quality of life scores were measured at baseline and months 1, 3, 6, and 12 after the beginning of vitamin D3 administration. Among 149 patients, 90% were vitamin D deficient. After vitamin D supplementation, health-related quality of life and fatigue scores improved significantly. There was a direct association between health-related quality of life with absence of fatigue and vitamin D status at the end of study. The 90% frequency of multiple sclerosis patients with vitamin D deficiency, together with the significant association of vitamin D status with the absence of fatigue and improved physical and functional well-being, p...Continue Reading

References

Oct 1, 2005·Multiple Sclerosis : Clinical and Laboratory Research·Megan M Smith, Peter A Arnett
Dec 21, 2006·JAMA : the Journal of the American Medical Association·Kassandra L MungerAlberto Ascherio
Feb 13, 2007·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·Kadriye ArmutluRana Karabudak
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Oct 2, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A LerdalA A Dahl
Feb 1, 2011·Multiple Sclerosis : Clinical and Laboratory Research·C VeauthierJ P Sieb
Mar 10, 2011·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Dec 21, 2011·Multiple Sclerosis : Clinical and Laboratory Research·M KaminskaD A Trojan
Jan 30, 2013·The EPMA Journal·Jan DörrFriedemann Paul
Jul 10, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Vittorio MartinelliGiancarlo Comi
Dec 24, 2013·Sleep Medicine·Christian Veauthier, Friedemann Paul
Jan 22, 2014·JAMA Neurology·Alberto AscherioChristoph Pohl
Oct 26, 2014·Multiple Sclerosis : Clinical and Laboratory Research·Anat AchironYoram Barak
Jul 30, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Janina R BehrensJan Dörr
Nov 17, 2015·Neurology. Neuroimmunology and Neuroinflammation·Dalia L RotsteinTanuja Chitnis
Jul 5, 2016·Neurologia i neurochirurgia polska·Katarzyna KępczyńskaBeata Zakrzewska-Pniewska
Nov 2, 2016·The EPMA Journal·Olga GolubnitschajaVincenzo Costigliola
Sep 30, 2017·Neurology. Neuroimmunology and Neuroinflammation·Marc PawlitzkiStefanie Schreiber
Oct 14, 2017·Nature Reviews. Neurology·Iris-Katharina Penner, Friedemann Paul
Dec 21, 2017·Neurology. Neuroimmunology and Neuroinflammation·Gunnar GaedeFriedemann Paul
Feb 13, 2018·Neurology. Neuroimmunology and Neuroinflammation·Burcu ZeydanOrhun H Kantarci
Mar 20, 2018·Journal of Neurology, Neurosurgery, and Psychiatry·Jana PöttgenStefan M Gold
May 16, 2019·Neurology. Neuroimmunology and Neuroinflammation·J Nicholas BrentonMyla D Goldman
Aug 28, 2019·Neurology. Neuroimmunology and Neuroinflammation·Chenyu WangAlexander Klistorner
Aug 28, 2019·Neurology. Neuroimmunology and Neuroinflammation·William CamuJean Claude Souberbielle

❮ Previous
Next ❯

Citations

Sep 3, 2020·The Journal of Clinical Endocrinology and Metabolism·Karlijn PellikaanLaura C G de Graaff
Feb 6, 2021·Multiple Sclerosis and Related Disorders·Steve Simpson-YapGeorge Jelinek

❮ Previous
Next ❯

Software Mentioned

GPower
MSQOLI

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.