Vitamin D deficiency impairs skeletal muscle function in a smoking mouse model

The Journal of Endocrinology
Nele CielenGhislaine N Gayan-Ramirez

Abstract

Chronic obstructive pulmonary disease (COPD) is associated with skeletal muscle dysfunction. Vitamin D plays an important role in muscle strength and performance in healthy individuals. Vitamin D deficiency is highly prevalent in COPD, but its role in skeletal muscle dysfunction remains unclear. We examined the time-course effect of vitamin D deficiency on limb muscle function in mice with normal or deficient vitamin D serum levels exposed to air or cigarette smoke for 6, 12 or 18 weeks. The synergy of smoking and vitamin D deficiency increased lung inflammation and lung compliance from 6 weeks on with highest emphysema scores observed at 18 weeks. Smoking reduced body and muscle mass of the soleus and extensor digitorum longus (EDL), but did not affect contractility, despite type II atrophy. Vitamin D deficiency did not alter muscle mass but reduced muscle force over time, downregulated vitamin D receptor expression, and increased muscle lipid peroxidation but did not alter actin and myosin expression, fiber dimensions or twitch relaxation time. The combined effect of smoking and vitamin D deficiency did not further deteriorate muscle function but worsened soleus mass loss and EDL fiber atrophy at 18 weeks. We conclude that th...Continue Reading

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Citations

Jul 13, 2016·Infection and Immunity·Julia NiederstrasserRobert Bals
Mar 5, 2019·European Journal of Applied Physiology·Katarzyna Patrycja Dzik, Jan Jacek Kaczor
Jan 23, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tom Tanjeko AjimeGhislaine Gayan-Ramirez
Oct 25, 2017·American Journal of Respiratory and Critical Care Medicine·Raolat M AbdulaiStephen I Rennard
Mar 19, 2021·Respiratory Research·Jef SerréGhislaine Gayan-Ramirez
May 4, 2021·Frontiers in Physiology·Christine M LathamJean L Fry

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Methods Mentioned

BETA
lavage
biopsies

Software Mentioned

SAS
InExpose

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