Vitamin D deficiency in a man with multiple myeloma.

North American Journal of Medical Sciences
Zackariah ClementSeeva Sivakumaran

Abstract

Vitamin D deficiency is extremely common in multiple myeloma, and it represents a surrogate for clinical multiple myeloma disease status. Patients may complain of dull, persistent, generalized musculoskeletal aches and pains with fatigue or decrease in muscle strength. A 63 year old male with multiple myeloma on Bortezomib presented with worsening generalized musculoskeletal pain, weakness, and multiple falls. On initial examination he was pale with a depressed affect. He had resting tremor, generalized bony tenderness, worse on movement and weight bearing, muscle weakness, and a waddling gait. His bone studies showed features of osteomalacia with a very low Vitamin D level of less than 20 nmol/L. He was treated with 3000 units of Vitamin D daily and physiotherapy. After 4 months, although his multiple myeloma deteriorated, there was a significant decrease in his generalized musculoskeletal pain. This case highlights that vitamin D deficiency is common in patients with multiple myeloma, and can cause generalized musculoskeletal pain and increase the risk of falls, yet it often goes unrecognized. In patients with non-specific musculoskeletal pain, and inadequate sun-exposure medical practitioners must have a high index of suspic...Continue Reading

Citations

Jul 3, 2013·North American Journal of Medical Sciences·Khalid RasheedEric Bixby
Oct 28, 2015·Cancer Investigation·Beate Lauter, Ingo G H Schmidt-Wolf
Feb 24, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·James WangJames R Berenson
Sep 25, 2019·International Journal of Molecular Sciences·Juan Luis Fernández-MartínezAndrzej Kloczkowski

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