Vitamin D deficiency in the aetiology of obesity-related insulin resistance

Diabetes/metabolism Research and Reviews
Adriyan PramonoE E Blaak

Abstract

The obese insulin-resistant state is often associated with low circulating concentration of vitamin D 25-hydroxyvitamin D3 [25(OH)D3 ]. Fat sequestration of vitamin D in the expanded obese adipose tissue mass has been pointed out as a plausible explanation for this circulating vitamin D deficiency. However, the putative mechanisms behind this hypovitaminosis D remain to be elucidated. The presence of vitamin D receptor and vitamin D-metabolizing enzymes in insulin-sensitive organs suggests that vitamin D may be involved in glucose and lipid metabolism and may be related to insulin sensitivity. Indeed, mainly in vitro studies support a role of vitamin D in regulating glucose and lipid metabolism in several insulin-sensitive tissues including adipose tissue, skeletal muscle, liver, as well as pancreatic insulin secretion. A potential role of vitamin D in gut barrier function and metabolism has also been suggested. This review summarizes recent knowledge on vitamin D deficiency in the aetiology of obesity-related insulin resistance and discusses potential underlying mechanisms. Finally, the role of vitamin D supplementation on insulin sensitivity and glycaemic control is discussed.

References

Mar 1, 1971·The Journal of Clinical Investigation·S J RosenstreichW Volwiler
May 2, 2000·Journal of Biochemistry·S Kato
Sep 1, 2000·The American Journal of Clinical Nutrition·J WortsmanM F Holick
Oct 19, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H ShiM B Zemel
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B XueM B Zemel
Apr 25, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Begoña MaestroConsuelo Calle
Apr 29, 2004·The American Journal of Clinical Nutrition·Ken C ChiuMohammed F Saad
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Scott M Grundy
Oct 30, 2004·The Journal of Nutrition·R H Wasserman
Dec 6, 2005·International Journal of Epidemiology·Andrew M Prentice
Feb 10, 2006·The Journal of Biological Chemistry·Jeffrey M BlumbergAnthony N Hollenberg
Feb 28, 2006·Apoptosis : an International Journal on Programmed Cell Death·R RiachyF Pattou
Oct 7, 2006·The American Journal of Clinical Nutrition·Lisa A Houghton, Reinhold Vieth
Feb 3, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Hermes FlorezSilvina Levis
Apr 13, 2007·Physiological Reviews·David B SavageGerald I Shulman
Jul 13, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·José I Botella-CarreteroHéctor F Escobar-Morreale
Aug 28, 2007·Nature Reviews. Cancer·Kristin K DeebCandace S Johnson
Dec 7, 2007·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Giuseppe LippiGiovanni Targher
Jun 14, 2008·Diabetes/metabolism Research and Reviews·Qiu Gen ZhouXun Zhang
Aug 12, 2008·The American Journal of Clinical Nutrition·Anthony W Norman
Aug 12, 2008·The American Journal of Clinical Nutrition·Robert P Heaney
Oct 1, 2008·Progress in Lipid Research·Giovanni MussoMaurizio Cassader
Oct 9, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Jia LiDorothy Teegarden
Nov 13, 2009·Diabetes Care·Vivian A Fonseca
Jun 1, 2010·Endocrinology and Metabolism Clinics of North America·J Wesley Pike, Mark B Meyer
May 27, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ryohei KasedaAkihiko Saito
Jun 23, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·C P EarthmanS D Sibley
Jun 24, 2011·The Journal of Nutrition·Han Seok ChoiSung-Kil Lim
Aug 30, 2011·Best Practice & Research. Clinical Endocrinology & Metabolism·Mark R HausslerAnthony W Norman
Apr 11, 2012·Diabetic Medicine : a Journal of the British Diabetic Association·P S GeorgeM D Witham
Apr 18, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·D GaoC Bing
Jun 12, 2012·Lancet·Adam G TabákMika Kivimäki
Jul 17, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shivaprakash J MuttKarl-Heinz Herzig
Jul 26, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L WambergS B Pedersen
Oct 16, 2012·Molecular Nutrition & Food Research·Julie MarcotorchinoJean-François Landrier
Nov 22, 2012·Endocrine Reviews·Christian M GirgisJenny E Gunton

❮ Previous
Next ❯

Citations

Jun 18, 2019·Nutrition Research Reviews·Karina Romeu MontenegroPhilip Newsholme
Sep 24, 2019·Canadian Journal of Physiology and Pharmacology·Mihaela IonicaDanina M Muntean
May 21, 2020·Nutrients·Luigi BarreaSilvia Savastano
Mar 4, 2021·Hormone Molecular Biology and Clinical Investigation·Karel Vondra, Richard Hampl
May 19, 2021·Hormone Molecular Biology and Clinical Investigation·Mehrdad HaghighiHasan Afzali
Nov 17, 2021·Critical Reviews in Food Science and Nutrition·Zhiwei JiangGuoli Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asprosin

Asprosin is a fasting-induced hormone produced in the white adipose tissue to stimulate the hepatic release of glucose into the bloodstream. Discover the latest research on this protein hormone here.

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ruben NogueirasMatthias H Tschöp
European Journal of Clinical Investigation
Horng-Yih OuKen C Chiu
The American Journal of Clinical Nutrition
Ken C ChiuMohammed F Saad
© 2022 Meta ULC. All rights reserved