Vitamin D deficiency is associated with poor outcomes and increased mortality in severely ill patients

QJM : Monthly Journal of the Association of Physicians
Y ArnsonH Amital

Abstract

Vitamin D plays a seminal role in many homeostatic mechanisms. In this study, we assessed the correlation between circulating vitamin D levels and mortality rates in critically ill patients. All patients admitted to the intensive care units (ICUs) and internal medicine wards in a university-based hospital that required mechanical ventilation were admitted. Data collected included the underlying disease, basic hematological and biochemical blood test results, APACHE II scores and serum 25-hydroxyvitamin D [25(OH)D] levels. The primary end point was defined as all-cause mortality within 60 days from admission or from acute deterioration. Between December 2008 and June 2009, 130 patients were enrolled. Average vitamin D concentration was 14.04 ± 6.9 ng/ml; 107 patients were vitamin D deficient (< 20 ng/ml). Total mortality rate after 60 days was 44.3%. Vitamin D levels were correlated with white blood cell (WBC) count, but with no other measured variable. Among the deceased patients, survival curves indicated that survival of patients with vitamin D deficiency was significantly shorter than those whose vitamin D concentration was >20 ng/ml (P < 0.05); the average survival time was 15.3 ± 12.4 days for vitamin D deficient patients ...Continue Reading

References

Jan 1, 1986·Journal of Molecular and Cellular Cardiology·M R WaltersP C Riggle
Aug 1, 1994·Journal of Cellular Biochemistry·Y Abu-Amer, Z Bar-Shavit
May 1, 1993·American Journal of Hypertension·R D Bukoski, H Xue
Mar 20, 1998·The New England Journal of Medicine·M K ThomasJ S Finkelstein
Feb 10, 2000·Archives of Biochemistry and Biophysics·C M VeldmanH F DeLuca
Apr 25, 2000·Biochemical and Biophysical Research Communications·M D GriffinR Kumar
Feb 16, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·U LangeG Neeck
Jan 1, 2003·Journal of Neuroimmunology·B D MahonM T Cantorna
Nov 24, 2005·International Journal of Epidemiology·Cedric F Garland, Frank C Garland
Feb 4, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Merav Cohen-LahavAmos Douvdevani
Sep 9, 2006·Epidemiology and Infection·J J CannellE Giovannucci
Jan 20, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Anthony W NormanPaul Lips
Jun 15, 2007·Annals of the Rheumatic Diseases·Yoav ArnsonYehuda Shoenfeld
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Feb 5, 2008·International Journal of Epidemiology·Kelechi E Nnoaham, Aileen Clarke
Jun 11, 2008·Archives of Internal Medicine·Edward GiovannucciEric B Rimm
Jul 19, 2008·Stroke; a Journal of Cerebral Circulation·Stefan PilzWinfried März
Nov 4, 2008·Endocrine·Liviu G DanescuJoseph Levy
Apr 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jun TangRachel R Caspi
May 1, 2009·The New England Journal of Medicine·Paul LeeJacqueline R Center
Jun 3, 2009·Critical Care Medicine·John C MarshallUNKNOWN International Sepsis Forum
Jun 23, 2009·Clinical Reviews in Allergy & Immunology·Yinon ShapiraYehuda Shoenfeld
Oct 31, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·Anastassios G PittasEdward Saltzman
Feb 12, 2010·Autoimmunity Reviews·Christina F PelajoLaurie C Miller
May 4, 2010·The Journal of Clinical Hypertension·Samuel J Mann, Linda M Gerber
Aug 21, 2010·Journal of Food Science·Yu-Ting KuoChih-Hsing Hung
Sep 28, 2010·Journal of the American Dietetic Association·Cheryl D TonerJohn A Milner
Dec 2, 2010·The Journal of Clinical Endocrinology and Metabolism·A Catharine RossSue A Shapses
Mar 26, 2011·Public Health Nutrition·Edward Giovannucci
May 31, 2011·Autoimmunity Reviews·Evelyn PeelenJan Damoiseaux
Nov 11, 2011·The American Journal of Cardiology·James L VacekPatricia A Howard

❮ Previous
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Citations

Oct 19, 2012·Current Opinion in Clinical Nutrition and Metabolic Care·Sadeq A Quraishi, Carlos A Camargo
Jun 7, 2013·PloS One·H Bryant NguyenDavid Baylink
Aug 2, 2013·Immunotherapy·Mandana Izadpanah, Hossein Khalili
Jan 24, 2014·Critical Care Research and Practice·Gulbin AygencelHatice Pasaoglu
Jul 17, 2014·American Journal of Respiratory and Critical Care Medicine·David E LeafSushrut S Waikar
Nov 8, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·N ClancyE J Molloy
Oct 23, 2013·The Veterinary Clinics of North America. Small Animal Practice·Marie K Holowaychuk
Dec 6, 2014·Critical Care : the Official Journal of the Critical Care Forum·Kim de HaanArd Struijs
Aug 29, 2013·Critical Care Medicine·Takuhiro MoromizatoKenneth B Christopher
Nov 20, 2015·Journal of Pediatric Hematology/oncology·Vineeta GuptaSurya K Singh
Apr 14, 2016·Annals of Medicine·W A C Kristine Koekkoek, Arthur R H van Zanten
Mar 25, 2015·European Journal of Pediatrics·Dana Ben-Ami ShorHoward Amital
Apr 18, 2015·BMC Cancer·Germaine WongRichard Prince
Apr 19, 2015·Critical Care : the Official Journal of the Critical Care Forum·David E LeafSushrut S Waikar
May 15, 2015·Indian Journal of Pediatrics·Shailender PrasadSona Chowdhary
May 27, 2014·International Journal of Pediatrics·Devi DayalSunit Singhi
Apr 23, 2013·The American Journal of Medicine·Muhammad Amer, Rehan Qayyum
Jan 31, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·Kenneth B Christopher
Jun 14, 2016·Acta Anaesthesiologica Scandinavica·R B KvaranG H Sigurdsson
Jul 15, 2015·American Journal of Therapeutics·Sarah Williams, Roschelle Heuberger
Apr 14, 2017·International Journal of Immunogenetics·K ZeljicB Bozic
Mar 29, 2018·PloS One·Jared A JaffeyAmy E DeClue
Oct 30, 2016·Journal of the American Heart Association·Michael E GerlingLawrence de Koning
Nov 17, 2017·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Nazik AşılıoğluMuhammed Sükrü Paksu
Dec 29, 2016·Journal of the American Society of Nephrology : JASN·David E LeafSushrut S Waikar
Nov 2, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Ghazaleh EslamianZahra Vahdat Shariatpanahi
Feb 25, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Ji-Hyun LeeJae-Myeong Lee
Sep 3, 2014·American Journal of Critical Care : an Official Publication, American Association of Critical-Care Nurses·Megan A RechJennifer Rodriguez
Sep 6, 2019·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Mohammad Amin Valizade HasanloeiReza Hashemi
May 26, 2017·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Enas AnwarMohamed H Attia
Dec 1, 2017·JPEN. Journal of Parenteral and Enteral Nutrition·Shweta S NamjoshiLaura J Wozniak
Oct 30, 2018·Critical Care : the Official Journal of the Critical Care Forum·Priya NairJacqueline R Center
Jul 1, 2017·The Journal of Veterinary Medical Science·Dong-In KimMhan-Pyo Yang
Oct 23, 2019·Journal of Veterinary Emergency and Critical Care·Dava M CazzolliKen Lamb

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