Vitamin D deficiency predicts severe acute pancreatitis

United European Gastroenterology Journal
Ji Hye HuhKyong Joo Lee

Abstract

The ability to predict the severity of disease is important to reduce morbidity and mortality in patients with acute pancreatitis (AP). Vitamin D deficiency has been associated with severity in various diseases. This study was conducted to assess vitamin D as a predictor of disease severity in patients with AP. Patients with AP were prospectively enrolled at Yonsei University Wonju College of Medicine from March 2015 to September 2017. Serum vitamin D was analyzed as soon as AP was diagnosed. The level of vitamin D was classified as normal (>20 ng/ml), insufficient (>10 and ≤20 ng/ml) or deficient (≤10 ng/ml). Among 242 patients with AP, the prevalence of vitamin D deficiency was 56.2%, and 28.5% of patients had vitamin D insufficiency. Serum vitamin D level was negatively correlated with severity indexes, such as the Atlanta classification, Computed Tomography Severity Index, Bedside Index for Severity of Acute Pancreatitis, and Ranson score. The prevalence of vitamin D deficiency increased with severity of AP according to the Atlanta classification. Vitamin D deficiency was the independent factor for predicting severe AP (OR 5.37, 95% CI 1.13-25.57, p = 0.015) and intensive care unit admission (OR 3.09, 95% CI 1.24-7.69, p = ...Continue Reading

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Citations

Mar 18, 2019·Internal and Emergency Medicine·Anna LicataMaurizio Soresi
Aug 12, 2020·Journal of Hepato-biliary-pancreatic Sciences·Reham I El-MahdyAmal Hosni
Apr 24, 2020·Oxidative Medicine and Cellular Longevity·Weiwei ChenWeiqin Li
Apr 16, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martin KaufmannGlenville Jones

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