Vitamin D Dosing Strategies Among Jordanians With Hypovitaminosis D

Journal of Pharmacy Practice
Nahla KhawajaKamel Ajlouni

Abstract

To compare between weekly and daily cholecalciferol in patients with hypovitaminosis D and to determine the optimal maintenance dose. Seventy-one volunteers with hypovitaminosis D were randomly assigned to 2 dose regimens: cholecalciferol 50 000 IU weekly for 8 weeks, then 50 000 IU monthly for 2 months (group A) and 7000 IU daily for 8 weeks, then 12 500 IU weekly for 2 months (group B). Cholecalciferol was stopped for 2 months and reintroduced as 50 000 IU bimonthly for group A and 50 000 IU monthly for group B. Two months after therapy, the mean serum 25-hydroxyvitamin D (25(OH)D) level increased from 11.4 to 51.2 ng/mL and from 11.7 to 44.9 ng/mL in groups A and B, respectively ( P = .065). The levels of 25(OH)D declined similarly in both groups during maintenance and after holding therapy. After resuming cholecalciferol, 25(OH)D levels increased to 33.8 and 28.8 ng/mL in groups A and B, respectively ( P = .027). There was a negative correlation between serum 25(OH)D levels and body mass index (BMI; P = .040). Timing and frequency of the dosing (daily vs weekly) have no effect on the rise in serum 25(OH)D levels as long as the accumulative dose of cholecalciferol is similar. Cholecalciferol 50 000 IU bimonthly is required t...Continue Reading

References

Nov 1, 1975·American Journal of Physical Anthropology·R M Neer
Nov 4, 1989·Lancet·M F HolickJ Wortsman
Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M C ChapuyP J Meunier
Oct 28, 1998·Physiological Reviews·G JonesH F DeLuca
Sep 1, 2000·The American Journal of Clinical Nutrition·J WortsmanM F Holick
Jan 24, 2002·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A A Mishal
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Shamik J ParikhJack A Yanovski
Jun 16, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N MeddebS Sellami
Jul 1, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Reinhold Vieth
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Laura A G ArmasRobert P Heaney
Dec 9, 2004·The American Journal of Clinical Nutrition·Hector F DeLuca
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickAnne E de Papp
Dec 29, 2005·American Journal of Public Health·Cedric F GarlandMichael F Holick
Feb 14, 2007·Clinical Therapeutics·Margaret E Kruk, Nina Schwalbe
Jun 9, 2007·The American Journal of Clinical Nutrition·Hussein F SaadiNicolaas Nagelkerke
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Sep 18, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·V ChelP Lips
Mar 6, 2008·European Journal of Nutrition·Steinar KonradsenRolf Jorde
Jun 12, 2008·The Journal of Clinical Endocrinology and Metabolism·Sophia Ish-ShalomReinhold Vieth
Aug 8, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Asif Bhutto, John E Morley
Mar 25, 2009·Archives of Internal Medicine·Adit A GindeCarlos A Camargo
Jun 27, 2009·Nutrition Research Reviews·Dorothy Teegarden, Shawn S Donkin
Apr 7, 2010·The Journal of Steroid Biochemistry and Molecular Biology·John J McGrathDarryl W Eyles
May 5, 2010·Molecular Nutrition & Food Research·Susan J Whiting, Mona S Calvo
Dec 2, 2010·The Journal of Clinical Endocrinology and Metabolism·A Catharine RossSue A Shapses
Dec 17, 2010·The Journal of Clinical Endocrinology and Metabolism·A J SaiJ C Gallagher
Jan 22, 2011·Annals of Nutrition & Metabolism·A BatiehaK Ajlouni
Feb 10, 2011·Annals of Nutrition & Metabolism·Mahmoud Ali KaykhaeiSaeid Ghavami
Apr 22, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Khalid K Abdul-RazzakBayan A Obeidat
Jun 1, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M-S M ArdawiA A Maimani
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Jan 26, 2012·Current Opinion in Gastroenterology·Pornpoj Pramyothin, Michael F Holick
Mar 15, 2012·European Journal of Clinical Nutrition·E K NicholsM K Serdula
Apr 26, 2012·BMC Women's Health·Abdellah El MaghraouiImad Ghozlani
May 9, 2012·European Journal of Internal Medicine·Walid SalibaGad Rennert
Nov 19, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Cristina Palacios, Lilliana Gonzalez
Jan 22, 2014·JAMA Neurology·Alberto AscherioChristoph Pohl
May 16, 2014·European Journal of Clinical Investigation·Monica VerdoiaGiuseppe De Luca
May 31, 2014·Metabolism: Clinical and Experimental·Maha HoteitGhada El-Hajj Fuleihan
Jul 6, 2014·European Journal of Clinical Nutrition·M K SerdulaUNKNOWN Jordan Fortification Working Group
Jul 9, 2014·Journal of the American Board of Family Medicine : JABFM·Gurmukh Singh, Aaron J Bonham
Aug 15, 2014·European Journal of Clinical Nutrition·E K NicholsK M Sullivan

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Jul 5, 2017·Nutrients·Luca Dalle CarbonareAngelo Pietrobelli

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