Vitamin D Effect on Bone Mineral Density and Fractures

Endocrinology and Metabolism Clinics of North America
Ian R Reid

Abstract

One hundred years ago, vitamin D was identified as the cause and cure of osteomalacia. This role remains firmly established. Vitamin D influences skeletal mineralization principally through the regulation of intestinal calcium absorption. It has been proposed that vitamin D has direct beneficial effects on bone (besides the prevention of osteomalacia), but these have been difficult to establish in clinical trials. Meta-analyses of vitamin D trials show no effects on bone density or fracture risk when the baseline 25-hydroxyvitamin D is >40 nmol/L. A daily dose of 400 to 800 IU vitamin D3 is usually adequate to correct such deficiency.

Citations

Oct 13, 2018·Chronobiology International·Agnieszka Bukowska-DamskaBeata Peplonska
Sep 20, 2018·Journal of Internal Medicine·I R Reid
Jan 17, 2019·Endocrine Connections·Stefan PilzMarlene Pandis
Aug 14, 2020·Journal of the American College of Nutrition·Shinwon LeeSun Hee Lee
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Mar 3, 2020·Clinics in Orthopedic Surgery·Gajendra Mani ShahGoo Hyun Baek
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Oct 17, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michaela KuhlenAdriana Balduzzi
Mar 12, 2021·Advances in Rheumatology·Kaiyu PanZhongxin Zhu
Apr 7, 2021·Pediatric Blood & Cancer·Rusha BhandariSaro H Armenian
Apr 10, 2021·Archives of Osteoporosis·De Hao LiuLi Chun Chen
Jun 9, 2021·Cancer Medicine·Jenneke E van AtteveldSebastian J C M M Neggers

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