Vitamin D for the Immune System in Cystic Fibrosis (DISC): a double-blind, multicenter, randomized, placebo-controlled clinical trial

The American Journal of Clinical Nutrition
Vin TangprichaJessica A Alvarez

Abstract

Patients with cystic fibrosis (CF) have increased risk of vitamin D deficiency owing to fat malabsorption and other factors. Vitamin D deficiency has been associated with increased risk of pulmonary exacerbations of CF. The primary objective of this study was to examine the impact of a single high-dose bolus of vitamin D3 followed by maintenance treatment given to adults with CF during an acute pulmonary exacerbation on future recurrence of pulmonary exacerbations. This was a multicenter, double-blind, placebo-controlled, intent-to-treat clinical trial. Subjects with CF were randomly assigned to oral vitamin D3 given as a single dose of 250,000 International Units (IU) or to placebo within 72 h of hospital admission for an acute pulmonary exacerbation, followed by 50,000 IU of vitamin D3 or an identically matched placebo pill taken orally every other week starting at 3 mo after random assignment. The primary outcome was the composite endpoint of the time to next pulmonary exacerbation or death within 1 y. The secondary outcomes included circulating concentrations of the antimicrobial peptide cathelicidin and recovery of lung function as assessed by the percentage of predicted forced expiratory volume in 1 s (FEV1%). A total of ...Continue Reading

Associated Clinical Trials

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Citations

Jul 28, 2019·Calcified Tissue International·Karen MaesGhislaine Gayan-Ramirez
Nov 24, 2020·Nutrition and Cancer·Weijie WangWei Zuo
Nov 5, 2019·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Tanicia DaleyVin Tangpricha
Nov 17, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Charlie McLeodThomas L Snelling
Dec 23, 2020·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Márk Félix JuhászAndrea Párniczky
Sep 2, 2021·American Journal of Respiratory and Critical Care Medicine·Christopher H GossUNKNOWN STOP2 Investigators

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