Vitamin D improves vascular function and decreases monoamine oxidase A expression in experimental diabetes

Molecular and Cellular Biochemistry
Adrian SturzaSorin Olariu

Abstract

The active form of vitamin D, 1,25-dihydroxycholecalciferol (1,25(OH)2D3), was reported to improve vascular function in patients with diabetes, yet the underlying mechanisms remain to be fully elucidated. Monoamine oxidase (MAO), a mitochondrial enzyme, with two isoforms (A and B) that generates hydrogen peroxide (H2O2) as by-product, has been recently reported to contribute to the pathogenesis of endothelial dysfunction in diabetes. The present study assessed the interaction between vitamin D and MAO in the vascular wall in the setting of type 1 experimental diabetes. To this aim, diabetes was induced in male Wistar rats via a single injection of streptozotocin (STZ, 50 mg/kg, IP) and 1 month later thoracic aortas were harvested and used for organ bath studies and H2O2 measurements. MAO expression was assessed by immunohistochemistry and RT-PCR. Endothelial function was evaluated in isolated aortic rings in the absence vs. presence of 1,25(OH)2D3 (100 nM, 24 h incubation). In diabetic animals, we found a significant reduction in the endothelial-dependent relaxation to acetylcholine and an increased expression of the MAO-A isoform, respectively. Vitamin D significantly improved vascular function, mitigated oxidative stress and ...Continue Reading

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Citations

May 6, 2019·Canadian Journal of Physiology and Pharmacology·Adrian SturzaCălin M Popoiu
Sep 24, 2019·Canadian Journal of Physiology and Pharmacology·Mihaela IonicaDanina M Muntean
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Adrian SturzaEugen S Boia
May 1, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dimitri PapukashviliYulin Deng
Oct 8, 2020·Reviews in Endocrine & Metabolic Disorders·Francesco TecilazichAndrea Giustina
Mar 5, 2021·The World Journal of Men's Health·Patrizia D'Amelio
May 12, 2021·Journal of Cellular and Molecular Medicine·Ying ZhangZhirong Jiang
Nov 3, 2021·Redox Report : Communications in Free Radical Research·Emilija AtanasovskaNikola Labachevski

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