Vitamin D in Cardiovascular Disease

In Vivo
Alkippi NitsaMichael Koutsilieris

Abstract

Cardiovascular disease is the prevalent cause of morbidity and mortality in the world, affecting many millions of individuals every year. Atherosclerosis, a chronic inflammatory condition that involves different cell types, several cytokines and adhesion molecules, is the underlying cause of cardiovascular disease. Vitamin D is known to control skeletal patho/physiology, regulating calcium and phosphorus and bone remodeling along with other calcium-regulating hormones. However, several active metabolites of vitamin D can exert both direct action, mainly via vitamin D3 receptor trans-activation and indirect actions on several other tissues by an endocrine, autocrine and paracrine manners. With regard to cardiovascular disease, vitamin D deficiency has been associated with activation of the pro-inflammatory mechanism, promoting atherogenesis. There are several large-scale clinical studies, as well as meta-analyses that support this finding. However, it is still unclear whether the plasma 25-hydroxyvitamin D level can be used as a biomarker for future cardiovascular disease. Herein we review the studies reporting a causative role for vitamin D in cardiovascular disease.

Citations

Jan 22, 2019·Nature Reviews. Nephrology·Xiaoliang Wang, Joseph I Shapiro
Aug 2, 2019·Experimental Biology and Medicine·Mohammadhossein HassanshahiAndrea M Stringer
Jul 11, 2019·Archives of Physiology and Biochemistry·Raghad Khalid Al-IshaqDietrich Büsselberg
Sep 12, 2020·Lupus Science & Medicine·Mayra GiannelouClio P Mavragani
Apr 17, 2020·European Geriatric Medicine·Christian OudshoornFrancesco U S Mattace-Raso
Aug 4, 2020·Current Heart Failure Reports·Anastassios PhilippouMichael Koutsilieris
Jul 30, 2020·Stem Cells International·Shuang Jiang, Yuchen Guo
Nov 23, 2019·Obstetrical & Gynecological Survey·Abdelrahman AlAshqarMostafa A Borahay
Sep 15, 2020·Orthopedic Research and Reviews·Alexander ZargaranAlex Trompeter
Dec 19, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Hasan Abbas QazmoozMichael Maes
Apr 1, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Alexandra E ButlerStephen L Atkin
Apr 14, 2021·Current Problems in Cardiology·Vernie SohAmer Harky
Mar 19, 2020·Current Vascular Pharmacology·Ioanna Gouni-Berthold, Heiner K Berthold
Jul 9, 2021·International Journal of Clinical Practice·Sarah Al SharieAyman J Hammoudeh
Aug 7, 2021·Biomolecules·Thomas MüllerKatja Frommholz
Aug 28, 2021·Nutrients·Liliana Łykowska-SzuberIwona Krela-Kaźmierczak
Sep 30, 2021·Molecular Genetics & Genomic Medicine·Jiahao ChenDongfeng Zhang

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