Vitamin D in Synaptic Plasticity, Cognitive Function, and Neuropsychiatric Illness

Trends in Neurosciences
Phoebe E Mayne, Thomas H J Burne

Abstract

Over a billion people worldwide are affected by vitamin D deficiency. Although vitamin D deficiency is associated with impaired cognition, the mechanisms mediating this link are poorly understood. The extracellular matrix (ECM) has now emerged as an important participant of synaptic plasticity and a new hypothesis is that vitamin D may interact with aggregates of the ECM, perineuronal nets (PNNs), to regulate brain plasticity. Dysregulation of PNNs caused by vitamin D deficiency may contribute to the presentation of cognitive deficits. Understanding the molecular mechanisms underpinning the role of vitamin D in brain plasticity and cognition could help identify ways to treat cognitive symptoms in schizophrenia and other neuropsychiatric conditions.

Citations

Jul 1, 2020·Current Pharmaceutical Design·Flavia di Michele
Jul 8, 2020·Brain Sciences·Luca SteardoAndrea Fiorillo
Apr 3, 2020·Nature Reviews. Nephrology·Davide ViggianoGiovambattista Capasso
Mar 18, 2019·Internal and Emergency Medicine·Anna LicataMaurizio Soresi
Jul 10, 2019·Medicina·Giulia BivonaMarcello Ciaccio
Dec 19, 2020·International Journal of Molecular Sciences·Jacek BajHanna Karakula-Juchnowicz
Jul 23, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giulia BivonaMarcello Ciaccio
Dec 11, 2019·The International Journal of Biochemistry & Cell Biology·Ludmila A KasatkinaIrene O Trikash
Oct 30, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Hang ZhaoShuchun Chen
Jun 3, 2021·International Journal of Molecular Sciences·Maria LoginovaMaria Vedunova
Jun 3, 2021·International Journal of Molecular Sciences·Thayza Martins MelzerPatricia S Brocardo
Aug 9, 2021·Journal of the Neurological Sciences·Cristina AgliardiMario Clerici
Aug 18, 2021·Food Science & Nutrition·Yeonjae Angel LeeYoung Chul Youn
Nov 30, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Paolo MeneguzzoPatrizia Todisco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.