Vitamin D in the aetiology and management of polycystic ovary syndrome

Clinical Endocrinology
Rebecca L ThomsonJonathan D Buckley

Abstract

Vitamin D deficiency is common in women with polycystic ovary syndrome (PCOS), with the 67-85% of women with PCOS having serum concentrations of 25-hydroxy vitamin D (25OHD) <20 ng/ml. Vitamin D deficiency may exacerbate symptoms of PCOS, with observational studies showing lower 25OHD levels were associated with insulin resistance, ovulatory and menstrual irregularities, lower pregnancy success, hirsutism, hyperandrogenism, obesity and elevated cardiovascular disease risk factors. There is some, but limited, evidence for beneficial effects of vitamin D supplementation on menstrual dysfunction and insulin resistance in women with PCOS. Vitamin D deficiency may play a role in exacerbating PCOS, and there may be a place for vitamin D supplementation in the management of this syndrome, but current evidence is limited and additional randomized controlled trials are required to confirm the potential benefits of vitamin D supplementation in this population.

References

Nov 1, 1989·American Journal of Obstetrics and Gynecology·W E Stumpf, M E Denny
Aug 1, 1980·The Journal of Nutrition·B P Halloran, H F DeLuca
Oct 28, 1998·Physiological Reviews·G JonesH F DeLuca
Aug 5, 1999·Steroids·S Thys-JacobsJ P Bilezikian
May 10, 2003·Journal of Affective Disorders·Natalie L RasgonStanley G Korenman
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Sigrid ElsenbruchOnno E Janssen
Jul 23, 2005·Clinical Chemistry·Dimitrios PanidisEvanthia Diamanti-Kandarakis
Oct 4, 2005·The British Journal of Nutrition·Armin ZittermannReiner Koerfer
Nov 10, 2005·JAMA : the Journal of the American Medical Association·Laufey SteingrimsdottirGunnar Sigurdsson
Jun 14, 2006·Journal of Health Psychology·Melissa J Himelein, Samuel S Thatcher
Jul 11, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·R PasqualiU Pagotto
Aug 5, 2006·Clinical Endocrinology·T M BarberS Franks
Oct 19, 2006·Obstetrical & Gynecological Survey·Melissa J Himelein, Samuel S Thatcher
Dec 21, 2006·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·S HahnO E Janssen
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Nov 9, 2007·The New England Journal of Medicine·Roger BouillonPaul Lips
Jan 9, 2008·Circulation·Thomas J WangRamachandran S Vasan
Jun 11, 2008·Archives of Internal Medicine·Edward GiovannucciEric B Rimm
Sep 2, 2008·Journal of Midwifery & Women's Health·Pamela K Murphy, Carol L Wagner
Dec 5, 2008·Nutrition Reviews·Ann Prentice
Oct 22, 2008·Fertility and Sterility·Kalliopi KotsaJohn G Yovos
Feb 14, 2009·Archives of Gynecology and Obstetrics·Recep YildizhanMansur Kamaci
Feb 20, 2009·Clinical Endocrinology·Stefan PilzJacqueline M Dekker
Feb 24, 2009·Fertility and Sterility·Touraj MahmoudiZahra Ezabadi
Jun 9, 2009·Fertility and Sterility·Touraj Mahmoudi
Jun 27, 2009·Nutrition Research Reviews·Dorothy Teegarden, Shawn S Donkin
Jul 4, 2009·Taiwanese Journal of Obstetrics & Gynecology·Batool RashidiFarid Zayerii
Jul 11, 2009·Fertility and Sterility·Sebiha OzkanLubna Pal
Jul 25, 2009·European Journal of Endocrinology·E WehrB Obermayer-Pietsch
Jul 31, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Yumi FujimakiSonoko Misawa
Sep 19, 2009·American Journal of Epidemiology·Annamari KilkkinenAntti Reunanen
Mar 4, 2010·The Journal of Steroid Biochemistry and Molecular Biology·P Lips
Aug 17, 2010·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·G ParikhD Seto-Young

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Citations

Sep 21, 2013·European Journal of Endocrinology·Y H M Krul-PoelS Simsek
Jun 4, 2014·American Journal of Clinical Dermatology·Najwa Somani, Diane Turvy
Sep 26, 2013·The International Journal of Neuroscience·András HollóPéter Lakatos
Jan 17, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Mohd Ashraf GanieZaffar Amin Shah
Nov 18, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dania Al-JaroudiMohamad Al-Tannir
Jan 7, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Emel Kiyak CaglayanM Fevzi Polat
Dec 15, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Müberra Namli KalemHasan Kafali
Oct 23, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Laura BuggioPaolo Vercellini
Aug 11, 2015·Molecular Nutrition & Food Research·Anju E JohamBarbora de Courten
Sep 16, 2015·The Journal of Obstetrics and Gynaecology Research·Xin-Zhuan JiaLan Wei
Aug 1, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·M F SalesK B Gomes
Jun 14, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mariateresa GalleaRoberto Mioni
Jun 3, 2015·Nutrients·Filip A DabrowskiMiroslaw Wielgos
Jul 18, 2016·Reproductive Biology and Endocrinology : RB&E·V De LeoF Petraglia
Jul 19, 2016·Archives of Toxicology·Giovanna MuscogiuriAnnamaria Colao
Nov 30, 2016·The Journal of Endocrinology·Abhaya Krishnan, Sridhar Muthusami
Mar 28, 2017·Systems Biology in Reproductive Medicine·Shabnam BakhshalizadehMaryam Shabani Nashtaei
Jan 20, 2017·Reviews in Endocrine & Metabolic Disorders·Giovanna MuscogiuriFrancesco Orio
Jan 17, 2017·Clinical and Experimental Reproductive Medicine·Andon HestiantoroMuharam Natadisastra
Jun 1, 2017·Current Opinion in Obstetrics & Gynecology·Jason M FranasiakAntonio Pellicer
Jul 29, 2017·The Cochrane Database of Systematic Reviews·Marian G ShowellRoger J Hart
Aug 22, 2017·Journal of Assisted Reproduction and Genetics·Deepika GargZaher Merhi
Jan 1, 2013·Clinical Medicine Insights. Women's Health·Tiffany M Bohon, Marci A Goolsby
Jun 1, 2018·International Journal of Molecular Sciences·Meenakshi UmarAouatef I Chouchane
Jul 22, 2014·Clinical and Experimental Reproductive Medicine·Jin Ju KimJung Gu Kim
Aug 22, 2018·Pediatrics International : Official Journal of the Japan Pediatric Society·Onur AkınPeyami Cinaz
Sep 5, 2017·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Swapna SiddamallaManjula Bhanoori
May 31, 2018·Endocrine Connections·Katica Bajuk Studen, Marija Pfeifer
Jun 13, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Daniela Menichini, Fabio Facchinetti
Jul 25, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Kamal AdvaniSandesh Kamdi
Sep 1, 2013·Expert Review of Endocrinology & Metabolism·Dorte GlintborgMarianne Andersen
Apr 20, 2014·The Journal of Clinical Endocrinology and Metabolism·Eun Mi ChangWoo Sik Lee
Nov 12, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Antoaneta GatevaZdravko Kamenov
May 6, 2020·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Maria Salomé Bezerra EspinolaCesare Aragona

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