PMID: 2115738Jul 1, 1990Paper

Vitamin D-induced chronic hypercalcemia inhibits thick ascending limb NaCl reabsorption in vivo

The American Journal of Physiology
L N Peterson

Abstract

Chronic hypercalcemia (HC) induced by dihydrotachysterol (DHT) is associated with a nephrogenic concentrating defect. The purpose of the present study is to assess the effects of HC on thick ascending limb (TAL) NaCl reabsorption in vivo by use of micro stop-flow technique. Feeding DHT (4.25 mg/kg diet) to rats was associated with an increase in plasma [Ca] within 24 h from 2.21 +/- 0.049 to 2.71 +/- 0.047 mM (P less than 0.001), which remained elevated during the 7-day period of study. Ambient plasma arginine vasopressin (AVP) in polydipsic HC rats was 3.10 +/- 0.605 pg/ml, a value not different from that measured in pair-fed control rats (1.82 +/- 0.260 pg/ml). A urine-concentrating defect developed after 3 days and occurred without nephrocalcinosis or reduced glomerular filtration rate (GFR). The estimated TAL [NaCl] after all stop-flow periods in HC rats did not decrease to the same extent as in controls. The rate constant of NaCl reabsorption derived from linear regression analysis of the ln[NaCl] vs. time for 0-15 s was significantly reduced by 25% in the HC nephrons. In addition, the minimum [NaCl] established after 30-60 s of contact time increased by 36% in HC nephrons. These data provide evidence that reduced TAL NaCl...Continue Reading

Citations

Oct 22, 2002·American Journal of Physiology. Renal Physiology·Weidong WangSøren Nielsen
Oct 14, 2009·Current Opinion in Nephrology and Hypertension·Chunfa Huang, Richard Tyler Miller
Nov 20, 2003·American Journal of Physiology. Renal Physiology·Weidong WangSøren Nielsen
Aug 19, 2007·Current Opinion in Nephrology and Hypertension·Chunfa Huang, R Tyler Miller
Aug 9, 2013·American Journal of Physiology. Renal Physiology·Douglas K AtchisonWilliam H Beierwaltes
Jul 3, 2015·Physiology·Hakan R TokaPascal Houillier
Dec 12, 2001·American Journal of Physiology. Renal Physiology·Weidong WangSøren Nielsen
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Dairong WangNicholas R Ferreri
Jan 26, 2017·The Journal of Physiology·Natsuko TokonamiPascal Houillier
Mar 25, 2016·American Journal of Physiology. Renal Physiology·Matthias B Moor, Olivier Bonny
Nov 19, 2010·The Journal of Biological Chemistry·Seung-Kuy ChaR Tyler Miller

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