Vitamin D Insufficiency and Cognitive Function Trajectories in Older Adults: The Rancho Bernardo Study

Journal of Alzheimer's Disease : JAD
Gail A LaughlinL K McEvoy

Abstract

Evidence of a role for vitamin D (VitD) in cognitive aging is mixed and based primarily on extreme VitD deficiency. We evaluated the association of VitD insufficiency with cognitive function in older, community-dwelling adults living in a temperate climate with year-round sunshine. A population-based longitudinal study of 1,058 adults (median age 75; 62% women) who had cognitive function assessed and serum levels of 25-hydroxyvitaminD (25OHD) measured in 1997-99 and were followed for up to three additional cognitive function assessments over a 12-year period. Overall, 14% (n = 145) of participants had VitD insufficiency defined as 25OHD <30 ng/ml. Adjusting for age, sex, education, and season, VitD insufficiency was associated with poorer baseline performance on the Mini-Mental Status Exam (MMSE) (p = 0.013), Trails Making Test B (Trails B) (p = 0.015), Category Fluency (p = 0.006), and Long Term Retrieval (p = 0.019); differences were equivalent to 5 years of age. For those with VitD insufficiency, the odds of mildly impaired performance at baseline were 38% higher for MMSE (p = 0.08), 78% higher for Trails B (p = 0.017), and 2-fold higher for Category Fluency and Long Term Retrieval (both p = 0.001). VitD insufficiency was no...Continue Reading

References

Sep 1, 1992·Journal of the American Geriatrics Society·T N Tombaugh, N J McIntyre
Mar 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Feb 22, 1974·Nature·T C Stamp, J M Round
Jan 1, 1994·Stroke; a Journal of Cerebral Circulation·R B D'AgostinoW B Kannel
Nov 7, 1999·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P LipsM F Holick
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Mar 15, 2002·Trends in Endocrinology and Metabolism : TEM·Emmanuel GarcionDidier Wion
Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH
Jun 30, 2004·Psychology and Aging·Emilio FerrerBrian S Schwartz
Jul 9, 2004·The Journal of Clinical Endocrinology and Metabolism·N BinkleyM K Drezner
Jun 1, 1990·The Journal of Nutritional Biochemistry·T C ChenM F Holick
Jun 1, 1990·The Journal of Nutritional Biochemistry·T C ChenM F Holick
Dec 14, 2004·Journal of Chemical Neuroanatomy·Darryl W EylesJohn J McGrath
Dec 23, 2004·Clinical Chemistry·Diana M AntoniucciDeborah E Sellmeyer
Jun 2, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Denise G von MühlenElizabeth Barrett-Connor
Jun 14, 2005·American Journal of Physiology. Renal Physiology·Adriana S DussoEduardo Slatopolsky
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Oct 4, 2007·The Journal of Clinical Endocrinology and Metabolism·Gail A LaughlinJaclyn Bergstrom
Dec 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Joyce C McCann, Bruce N Ames
Jun 27, 2008·Molecular Aspects of Medicine·Jennifer S Buell, Bess Dawson-Hughes
Aug 12, 2008·The American Journal of Clinical Nutrition·Bruce W Hollis
Sep 20, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T-T L DamE L Barrett-Connor
Aug 8, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C AnnweilerO Beauchet
Nov 27, 2009·Neurology·Y SlininUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Jun 24, 2010·Behavioural Pharmacology·Adam StewartAllan V Kalueff
Sep 18, 2010·BMC Neuroscience·Claudia BartelsHannelore Ehrenreich
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Jun 23, 2011·Journal of Alzheimer's Disease : JAD·Mark S SteinLeonard C Harrison
Nov 15, 2011·Alzheimer's Research & Therapy·Steven D ShirkAlireza Atri
Dec 21, 2011·Annals of Internal Medicine·Cora McGreevy, David Williams
Mar 29, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yelena SlininUNKNOWN Study of Osteoporotic Fractures Research Group
Jul 5, 2012·Dementia and Geriatric Cognitive Disorders·Thorleif EtgenHans Förstl
Nov 28, 2012·Journal of the American Geriatrics Society·Rebecca C RossomKaren L Margolis
May 25, 2013·Endocrinology and Metabolism Clinics of North America·J Christopher Gallagher
Aug 21, 2013·Journal of Alzheimer's Disease : JAD·Cedric AnnweilerOlivier Beauchet
May 2, 2014·Frontiers in Aging Neuroscience·Cédric Annweiler, Olivier Beauchet
May 23, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A L C SchneiderE D Michos
Jul 6, 2014·Journal of Internal Medicine·C AnnweilerO Beauchet
Nov 25, 2014·Annals of Internal Medicine·Michael L LeFevre, UNKNOWN U.S. Preventive Services Task Force
Feb 20, 2015·JAMA : the Journal of the American Medical Association·JoAnn E Manson, Shari S Bassuk
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Bryna ShatensteinPatrizia Mecocci
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Elżbieta KuźmaDavid J Llewellyn

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Mar 2, 2019·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·M I da RosaF O Meller
May 31, 2019·Neurological Research·Giulia BivonaMarcello Ciaccio
May 14, 2020·Journal of Aging Research·Sadia SultanAmira Hazazi
Jun 11, 2020·Archives of public health = Archives belges de santé publique·Huijuan LiLige Song
Jul 10, 2019·Medicina·Giulia BivonaMarcello Ciaccio
Jan 8, 2021·Expert Review of Neurotherapeutics·Francesco PanzaMadia Lozupone
Jul 23, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Giulia BivonaMarcello Ciaccio

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