Vitamin D insufficiency, hemoglobin, and anemia in children with chronic kidney disease

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Kathleen E AltemoseMeredith A Atkinson

Abstract

25-Hydroxyvitamin D (25OHD) deficiency is common in children with chronic kidney disease (CKD). It has been associated with an increased risk for anemia in both healthy US children and in adults with CKD. This association has not been explored in children with CKD. Children aged 1-16 enrolled in the Chronic Kidney Disease in Children (CKiD) study with mild to moderate kidney dysfunction, and with 25OHD measured at baseline (n = 580), were included in the analysis. The cross-sectional associations between 25OHD and hemoglobin (g/dL) and anemia were assessed. Anemia was defined as hemoglobin < 5th percentile for age and sex. Overall 334 (57.59%) children were vitamin D insufficient/deficient and 137 (23.62%) were anemic. Of those who were vitamin D insufficient/deficient, 95 (28.44%) were anemic. In the overall cohort, the odds of being anemic was 1.9 times higher (95% CI, 1.22-3.04, p < 0.01) in vitamin D insufficient/deficient vs sufficient children, when adjusting for covariates (age, sex, race [black, white, or other], body mass index (BMI), iohexol GFR (iGFR), erythropoietin stimulation agent (ESA) use, iron supplementation use, and underlying cause of CKD). Stratified by race, the odds of being anemic was 2.39 times higher ...Continue Reading

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Citations

Jan 24, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Evgenia PrekaRukshana Shroff
Feb 6, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Meredith A AtkinsonJoseph T Flynn
Aug 28, 2021·British Journal of Clinical Pharmacology·Mandy WanJignesh P Patel

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