Vitamin D intake and breast cancer risk: a case-control study in Italy

Annals of Oncology : Official Journal of the European Society for Medical Oncology
M RossiC La Vecchia

Abstract

Vitamin D has been suggested to play a protective role against several cancers, including breast cancer. We used data from a case-control study conducted in Italy from 1991 to 1994 to study the relation between dietary intake of vitamin D and breast cancer risk. Subjects were 2569 women with incident, histologically confirmed breast cancer and 2588 hospital controls. Odds ratios (ORs) and 95% confidence intervals (CIs) according to deciles of vitamin D intake were estimated by multiple logistic regression models. After allowance for major risk factors for breast cancer and dietary covariates including calcium and energy intake, there was no association with vitamin D up to the seventh decile. Thereafter, the OR declined, so that the overall trend was statistically significantly inverse. The OR for subjects in the three highest deciles of consumption compared with those in the lowest ones combined was 0.79 (95% CI 0.70-0.90). Intake of vitamin D >3.57 microg or 143 IU appeared to have a protective effect against breast cancer. The inverse association was consistent across strata of menopausal status. This study adds to the existing evidence that vitamin D intake in inversely associated with breast cancer risk.

References

Dec 1, 1985·International Journal of Epidemiology·U FacchiniC La Vecchia
Sep 1, 1980·International Journal of Epidemiology·C F Garland, F C Garland
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S FranceschiG Panarello
Jan 17, 1996·International Journal of Cancer. Journal International Du Cancer·E NegriA Decarli
Dec 11, 1995·International Journal of Cancer. Journal International Du Cancer·S FranceschiA Giacosa
Feb 1, 1997·Breast Cancer Research and Treatment·J S WitteR W Haile
Apr 1, 1998·Journal of the National Cancer Institute·R A HiattN Orentreich
Oct 8, 1999·Public Health Nutrition·E C JanowskyB S Hulka
Feb 11, 2000·Annals of the New York Academy of Sciences·C F GarlandE D Gorham
Aug 6, 2000·Circulation Research·D J MantellA E Canfield
Jan 9, 2001·International Journal of Cancer. Journal International Du Cancer·F LeviC La Vecchia
Sep 5, 2002·Journal of the National Cancer Institute·Myung-Hee ShinWalter C Willett
Mar 13, 2003·Breast Cancer Research : BCR·A Lindsay FrazierGraham A Colditz
Feb 19, 2004·Cancer Causes & Control : CCC·A Lindsay FrazierGraham A Colditz
Dec 9, 2004·The American Journal of Clinical Nutrition·Joellen Welsh
May 4, 2005·Cancer Causes & Control : CCC·Edward Giovannucci
May 25, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lorraine C LoweKay W Colston
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Elizabeth R Bertone-JohnsonSusan E Hankinson
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Marjorie L McCulloughEugenia E Calle
Aug 10, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yan Cui, Thomas E Rohan
Mar 21, 2007·The Journal of Steroid Biochemistry and Molecular Biology·Cedric F GarlandFrank C Garland
Mar 21, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Julia A KnightReinhold Vieth
May 18, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jacques BrissonBenoît Mâsse
May 30, 2007·Archives of Internal Medicine·Jennifer LinShumin M Zhang
Jun 6, 2007·Cancer Causes & Control : CCC·Kim RobienDeAnn Lazovich
Jun 9, 2007·The American Journal of Clinical Nutrition·Joan M LappeRobert P Heaney
Aug 10, 2007·Environmental Health Perspectives·Ingrid A F van der MeiGraeme Jones
Sep 4, 2007·International Journal of Cancer. Journal International Du Cancer·Valeria EdefontiMonica Ferraroni
Apr 11, 2008·The American Journal of Clinical Nutrition·Amy E Millen, Lisa M Bodnar

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Citations

Oct 24, 2009·Breast Cancer Research and Treatment·Peizhan ChenHui Wang
Dec 2, 2011·Breast Cancer Research and Treatment·Dana E RollisonAnna R Giuliano
Oct 6, 2012·Critical Reviews in Food Science and Nutrition·Laura Vera-RamirezJose L Quiles
Jul 9, 2010·Menopause : the Journal of the North American Menopause Society·Elizabeth R Bertone-JohnsonAnne McTiernan
Sep 3, 2011·Breast Cancer Research : BCR·Rowan T Chlebowski
May 19, 2012·Endocrine Reviews·Clifford J RosenChristopher S Kovacs
Jan 12, 2012·The Oncologist·Theresa ShaoMichael L Grossbard
Oct 29, 2010·The American Journal of Clinical Nutrition·Elizabeth T JacobsJohn P Pierce
Apr 10, 2015·Pharmaceutical Biology·Marco GiammancoGaetano Leto
Nov 26, 2014·Cancer Causes & Control : CCC·Laura L ReimersMarilie D Gammon
Oct 30, 2016·Molecular Nutrition & Food Research·Nitin ShivappaCarlo La Vecchia
Jan 31, 2012·Head & Neck·Helena Orell-KotikangasAntti A Mäkitie
Jan 10, 2014·Endocrine·Daniel D Bikle
Aug 29, 2017·BioMed Research International·C M LopesR Oliveira
Sep 5, 2009·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Han van der RheeEsther de Vries
Aug 9, 2012·Breast Cancer Research and Treatment·Zhiqiang HongXingliang Zhang
Nov 22, 2012·International Journal of Cancer. Journal International Du Cancer·Abul Kalam AzadWei Xu
Jun 21, 2019·Medicina·Alexandra Iulia IrimieIoana Berindan-Neagoe
Aug 1, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jie WangWei Bao
May 24, 2013·The American Journal of Clinical Nutrition·Fatimah M YousefCynthia A Thomson
Jun 15, 2018·Scientific Reports·Nuria EstébanezTrinidad Dierssen-Sotos
Jun 21, 2019·The British Journal of Dermatology·U E LiyanageS MacGregor
Apr 16, 2010·The American Journal of Clinical Nutrition·Laura N AndersonJulia A Knight
Nov 16, 2012·Natural Product Reports·Jorge A R SalvadorM Luisa Sá e Melo
Jun 23, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Laura N AndersonJulia A Knight
Dec 4, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Pierre EngelFrancoise Clavel-Chapelon
Apr 6, 2021·European Journal of Nutrition·Cesar I Fernandez-LazaroEstefanía Toledo

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