Vitamin D levels and risk for periodontal disease: A systematic review

Journal of Periodontal Research
J P N S PintoA N Haas

Abstract

To evaluate the existing evidence supporting or refuting the following questions: (i) Do patients with lower vitamin D levels have higher risk for periodontal disease? (ii) Are periodontal treatment outcomes improved by the adjuvant supplementation of vitamin D or by elevated serum vitamin D levels? MEDLINE, SCOPUS, EMBASE and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched up to September 2017. Studies were included if they had measured serum vitamin D levels or vitamin D intake and any periodontal parameter. Overall, 27 studies were included (13 cross-sectional studies, 6 case-control studies, 5 cohort studies, 2 randomized clinical trials and 1 case series study). Sixty-five percent of the cross-sectional studies reported significant associations between low vitamin D levels and poor periodontal parameters. None of the observational longitudinal studies found that periodontal disease progression could be attributed to lower vitamin D levels. No interventional studies that evaluated the use of vitamin D supplementation as a solely adjuvant to periodontal treatment was found. No meta-analysis was performed due to high variability across studies. The data to support or refute the association bet...Continue Reading

References

May 2, 2003·The British Journal of Nutrition·Armin Zittermann
Sep 21, 2005·Journal of Periodontology·Charles F Hildebolt
Jan 25, 2006·Autoimmunity Reviews·Diane L KamenGary S Gilkeson
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Reinhold Vieth
Jun 22, 2010·American Journal of Epidemiology·Rachael Z Stolzenberg-SolomonLaurence N Kolonel
Aug 5, 2010·Journal of Periodontology·Rola Al HabashnehGeorgia K Johnson
Sep 3, 2010·Journal of Periodontology·Kim A BoggessCarlos A Camargo
Sep 3, 2010·Journal of Periodontology·M Nathalia GarciaRoberto Civitelli
Oct 19, 2010·The New England Journal of Medicine·Jill D BashutskiLaurie K McCauley
Mar 23, 2011·Infection and Immunity·Laura McMahonGill Diamond
Jan 1, 2010·Dermato-endocrinology·William B Grant, Barbara J Boucher
May 11, 2011·Journal of Dental Research·J D BashutskiL K McCauley
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Oct 15, 2011·Clinical Endocrinology·Martin Hewison
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Feb 3, 2012·Journal of Clinical Periodontology·Xuan ZhouZuomin Wang
Oct 4, 2012·Journal of Periodontology·Daniel JönssonRyan T Demmer
Dec 25, 2012·Journal of Periodontology·Amy E MillenJean Wactawski-Wende
Apr 12, 2013·Periodontology 2000·Robert J Genco, Wenche S Borgnakke
Jun 22, 2013·Journal of Dental Research·E N AlshouibiR I Garcia
Sep 21, 2013·Journal of Indian Society of Periodontology·Nithya AnandNarpat Singh Rajput
Nov 22, 2013·Journal of Periodontal Research·S H SteinD A Tipton
May 16, 2014·Journal of Dental Research·Y ZhanT Kocher
Jul 22, 2014·Journal of Periodontal Research·G N AntonoglouT Tervonen
Feb 17, 2015·Journal of Clinical Periodontology·A AmaliyaUbele Van der Velden
Apr 10, 2015·The Journal of Clinical Endocrinology and Metabolism·Ulrike Schulze-SpäteThuy-Tien Dam
May 6, 2015·Public Health Nutrition·Amanda Ra AdegboyeBerit L Heitmann
Jun 3, 2015·Community Dentistry and Oral Epidemiology·Hyo-Jin LeeKwang-Hak Bae
Jun 29, 2015·Autoimmunity Reviews·I HollanP L Meroni
Dec 3, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D C PenoniA T T Leão
May 11, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Sonia Maria Soares FerreiraLucio Souza Gonçalves
Jul 7, 2016·Journal of International Society of Preventive & Community Dentistry·Farhan R KhanZulfiqar A Bhutta
Sep 4, 2016·BMC Oral Health·Orlando J AbreuCristina Palacios
Oct 1, 2016·Clinical Oral Investigations·Markus LakyXiaohui Rausch-Fan

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Citations

Jul 28, 2020·Nutrients·Vanessa MachadoJoão Botelho
Jul 6, 2021·Saudi Journal of Biological Sciences·Abdullah Ali H AlzahraniAbdulmajeed Abdulghani A Sindi

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