Vitamin D Levels Are Unrelated to the Severity of Respiratory Syncytial Virus Bronchiolitis Among Hospitalized Infants

Journal of the Pediatric Infectious Diseases Society
Avraham BeigelmanLeonard B Bacharier

Abstract

Vitamin D deficiency at birth has been reported as a risk factor for respiratory syncytial virus (RSV) lower respiratory tract infection during the first year of life. Limited data are available on whether an infant's vitamin D status is associated with the severity of acute RSV bronchiolitis. Infants < 1 year of age and hospitalized with their first episode of RSV bronchiolitis were enrolled into the RSV Bronchiolitis in Early Life II cohort. We investigated the relationships between vitamin D status at enrollment and the following indicators of bronchiolitis severity: duration of hospitalization, lowest oxygen saturation measured during hospitalization, and bronchiolitis severity score. Among the 145 enrolled infants, the median (quartile 1 [Q1], Q3) serum 25-OH-VitD level was 36.8 (29.8, 42.3) ng/mL, with 14 infants (9.7%) having deficient serum vitamin D levels (25-OH-VitD <20 ng/mL). Vitamin D-deficient infants were younger than infants with 25-OH-VitD ≥ 20 ng/mL (2.8 vs 4.5 months, respectively; P = .04) and were less likely to consume infant's formula (42.9% vs 87.0%, respectively; P < .01). The following indicators of acute bronchiolitis severity did not differ between infants who were vitamin D-deficient and nondeficie...Continue Reading

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Citations

Sep 4, 2015·Journal of the Pediatric Infectious Diseases Society·Samir S ShahTodd A Florin
Feb 18, 2020·Influenza and Other Respiratory Viruses·Wei CaiWalter Haas
Jul 3, 2020·Japanese Journal of Infectious Diseases·Hisashi KawashimaYasuyo Kashiwagi
Sep 25, 2020·Nutrients·Maheen SiddiquiHadi M Yassine
Oct 24, 2020·Nutrients·Francesco PecoraSusanna Esposito
Mar 4, 2021·Pediatric Pulmonology·Maria PapadakiAlexandra Soldatou
Jul 10, 2021·PloS One·Vicka OktariaMargaret Danchin
Sep 3, 2021·Critical Reviews in Food Science and Nutrition·Mostafa Vaghari-TabariZatollah Asemi
Sep 29, 2021·Journal of Tropical Pediatrics·Yusuf AlakaşSelçuk Matyar

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