Vitamin D levels in children and adolescents with autism

The Journal of International Medical Research
Esma ŞengençSema Saltik

Abstract

This study aimed to investigate the relationship between autism spectrum disorder (ASD) and vitamin D levels in children and adolescents. We measured serum 25-hydroxyvitamin D (25-OHD) levels in 1529 patients with ASD aged 3 to 18 years, without any additional chronic diseases. Levels of 25-OHD were compared according to sex, age (<11 or ≥11 years), and birth season. Additionally, laboratory parameters (calcium, phosphorus, alkaline phosphatase, and 25-OHD) of 100 selected patients with ASD were compared with those of the healthy control group. Vitamin D deficiency or insufficiency was found in approximately 95% of all patients. Levels of 25-OHD in adolescent patients with ASD aged 11 to 18 years were significantly lower than those in patients aged younger than 11 years. In the 100 selected patients with ASD, mean serum 25-OHD levels were significantly lower and alkaline phosphatase levels were higher compared with those in healthy children. Our study suggests a relationship between vitamin D and ASD in children. Monitoring vitamin D levels is crucial in autistic children, especially adolescents, to take protective measures and treat this condition early.

References

Jan 1, 1995·Psychological Medicine·A BaileyM Rutter
Nov 14, 1998·Journal of Autism and Developmental Disorders·E Simonoff
Jun 16, 2000·Journal of Clinical and Experimental Neuropsychology·M C StevensL H Waterhouse
Feb 13, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Fred R VolkmarAmi Klin
Oct 6, 2005·Environmental Health Perspectives·Emily OkenMatthew W Gillman
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Apr 3, 2008·Pediatrics·Catherine LimperopoulosAdré J du Plessis
Jun 6, 2008·Archives of Pediatrics & Adolescent Medicine·Catherine M GordonJoanne E Cox
Aug 5, 2008·Pediatrics·Madhusmita MisraUNKNOWN Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society
May 26, 2010·Developmental Medicine and Child Neurology·Cynthia A MolloyMary L Hediger
Jun 24, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Nagwa A MeguidGloria Sidhom
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Jun 15, 2011·Molecular and Cellular Endocrinology·James P KesbyJohn J McGrath
Jan 31, 2012·Pediatric Clinics of North America·Erin Duchan, Dilip R Patel
Mar 8, 2012·Journal of Clinical Research in Pediatric Endocrinology·Nesibe AndıranGüzide Doğan
Apr 13, 2012·Autism Research : Official Journal of the International Society for Autism Research·Mayada ElsabbaghEric Fombonne
Apr 24, 2012·Research in Developmental Disabilities·Eva KočovskáChristopher Gillberg
Jun 4, 2013·Medical Hypotheses·John Jacob Cannell
Sep 18, 2013·International Journal of Women's Health·Abdulbari BenerNajah M Saleh
Mar 13, 2014·Attention Deficit and Hyperactivity Disorders·Madeeha KamalMohammad S Ehlayel
Jun 15, 2014·Journal of Autism and Developmental Disorders·Eva KočovskáChristopher Gillberg
Jul 18, 2014·Annual Review of Nutrition·Natalie J GrovesThomas H J Burne
Nov 5, 2014·Annals of Medical and Health Sciences Research·A BenerD Bhugra
Dec 17, 2014·Pediatrics·Feiyong JiaLin Du
Jan 13, 2016·Journal of Parkinson's Disease·Lisanne M RimmelzwaanElisabeth M W Eekhoff
May 6, 2016·Frontiers in Neuroscience·Takeo FujiwaraYukako Tani
Feb 22, 2017·Reviews in Endocrine & Metabolic Disorders·John Jacob Cannell
Apr 28, 2017·BJPsych Open·Anna A E VinkhuyzenJohn J McGrath
Jan 5, 2019·Journal of Molecular Neuroscience : MN·Geir BjørklundJoanna Kałużna-Czaplińska

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Citations

Jul 3, 2021·Life·Alessandra PecorelliGiuseppe Valacchi
Nov 5, 2021·Journal of Autism and Developmental Disorders·Maria Carmen Gallardo-CarrascoMaría Sánchez-Muñoz

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