PMID: 6981469Jul 1, 1982Paper

Vitamin D metabolism in hyperthyroidism

Clinical Endocrinology
I A MacFarlaneJ Hann

Abstract

The serum concentrations of 25-hydroxycholecalciferol (25 OH D3), 24,25-dihydroxycholecalciferol [24,25(OH)-2D3] and 1,25-dihydroxycholecalciferol [1,25(OH)2D3] were measured in twenty-one patients with untreated hyperthyroidism. Compared with control subjects, 25 OH D3 concentrations were not altered, 24,25(OH)2D3 concentrations were increased, although not significantly and 1,25(OH)2D3 concentrations were decreased (P = 0.01). Following oral carbimazole therapy, 24,25(OH)2D3 concentrations fell (P less than 0.01), 1,25(OH)2D3 concentrations increased (P less than 0.01) and 25 OH D3 concentrations were unchanged. The altered 1,25(OH)2D3 and 24,25(OH)2D3 concentrations found in hyperthyroidism are probably due to the effects of thyroid hormone on bone and mineral metabolism. Increased serum calcium and phosphate concentrations with secondary hypoparathyroidism result in stimulation of the renal 24-hydroxylase and suppression of the 1-hydroxylase enzymes. In addition, serum 24,25(OH)2D3 concentrations were significantly correlated with serum triiodothyronine levels (T3) (r = 0.66, P less than 0.002) before treatment. This may indicate a direct stimulatory effect of T3 on 24-hydroxylase activity. No relationship was found between...Continue Reading

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Citations

Nov 1, 1990·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D DevlinG K Worth
Jan 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R D DevlinG K Worth
Feb 19, 1999·Annals of Surgery·H YamashitaN Murakami
Oct 4, 2011·Indian Journal of Endocrinology and Metabolism·Dinesh Kumar Dhanwal
Jul 1, 1990·Journal of Endocrinological Investigation·G SaggeseG I Baroncelli
Aug 28, 2014·Aging Clinical and Experimental Research·Serap Baydur SahinEkrem Algun
Nov 6, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Hong ZhangZhongjian Xie
Jan 1, 1988·Journal of Endocrinological Investigation·G BenkerD Reinwein
Jan 17, 2017·Reviews in Endocrine & Metabolic Disorders·Immacolata Cristina NettorePaolo Emidio Macchia
Apr 1, 1995·Journal of Endocrinological Investigation·G WeberG Chiumello
Sep 1, 1991·Annals of Saudi Medicine·A Al-NuaimM Mohammadiah
Aug 30, 1985·Biochemical and Biophysical Research Communications·Y KashioT Fujita

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