Vitamin D metabolism in hypoparathyroidism

The Journal of Clinical Endocrinology and Metabolism
B LundA W Norman

Abstract

Only moderately reduced serum 1,25-dihydroxyvitamin D [1,25(OH)2D3] levels were found in 13 hypoparathyroid patients and in 1 pseudohypoparathyroid patient, indicating that factors other than parathyroid hormone are able to mediate the basal production of 1,25(OH)2D3. A significant correlation was found between the levels of circulating 25-hydroxyvitamin D (25OHD) and 1,25(OH)2D, suggesting that a high concentration of 25OHD was able to increase the renal production of 1,25(OH)2D, whereas hypocalcemia and changes in serum phosphate became less important in the present situation. The serum 25OHD and 1,25(OH)2D concentrations were followed during the change of treatment from ergocalciferol to 1 alpha-hydroxycholecalciferol (1 alpha-OHD3). A biological half-life of 3 weeks could be estimated for the plasma 25OHD. The increase in serum 1,25(OH)2D correlated with the dose of 1 alpha-OHD3 given, whereas no correlation was found between the serum calcium level and the 1,25(OH)2D concentration. Unexpected increases and decreases in serum calcium were observed at the same dose of 1 alpha-OHD3 in the same patient and at serum 1,25(OH)2D concentrations within the physiological range.

Citations

Jan 1, 1984·Archives of Dermatological Research·J Serup, H K Hagdrup
Apr 1, 1994·Atherosclerosis·H Gylling, T A Miettinen
Sep 1, 1984·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L BuskU G Ahlborg
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S Takase, T Goda
Oct 1, 1984·The Journal of Pediatrics·V A HusteadR D Zachman
Aug 1, 1987·Baillière's Clinical Endocrinology and Metabolism·J R Patsch
Jan 14, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·M H BoilyP A Spear
Jun 18, 2005·The Proceedings of the Nutrition Society·Alexis M Willett
Mar 5, 1983·British Medical Journal·T H MitchellJ L Berry
Mar 1, 1982·The Journal of Clinical Investigation·P W LambertN H Bell
Jul 1, 1985·The Journal of Clinical Investigation·N H Bell
Sep 27, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jean-Claude SouberbiellePhilippe Chanson
Dec 1, 1988·The American Journal of the Medical Sciences·N A Breslau
Dec 1, 1985·Mayo Clinic Proceedings·M Audran, R Kumar
Mar 1, 1984·Kidney International·D L AndressF Llach
Sep 1, 1988·Kidney International·A DussoE Slatopolsky
Jan 1, 1990·Kidney International·C H Hsu, S Patel
Jan 1, 1992·Bone and Mineral·K NakatsukaS Murakawa
May 1, 1989·The Journal of Pediatrics·S A AtkinsonR D Barr
Nov 1, 1982·The American Journal of Medicine·S GottleibF R Singer
Aug 12, 2008·The American Journal of Clinical Nutrition·Ann PrenticeInez Schoenmakers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.