Vitamin D metabolites are lower with active Crohn's disease and spontaneously recover with development of remission

Therapeutic Advances in Gastroenterology
Craig HaiferSimon Ghaly

Abstract

Vitamin D deficiency is associated with active Crohn's disease (CD). However, it remains unclear if lower 25-hydroxyvitamin D [25(OH)D] concentration is the cause, or consequence, of intestinal inflammation. Existing literature has focused on circulating 25(OH)D rather than the active metabolite 1,25(OH)2D, or its breakdown product, 24,25(OH)2D. We aimed to characterise vitamin D metabolism in a cohort of patients with active and inactive CD. Fifty-four patients with CD and not on corticosteroids or vitamin D supplements, were enrolled in a 6-month prospective cohort study. Sera were collected on enrolment and at 6 months and tested for 25(OH)D, 1,25(OH)2D, 24,25(OH)2D using liquid chromatography tandem mass spectroscopy as well as vitamin-D-binding protein. There were no differences in 25(OH)D or 1,25(OH)2D levels between participants with active versus inactive disease. Levels of 24,25(OH)2D were significantly lower in those with active compared with inactive disease (mean 3.9 versus 6.0 µmol/l; p = 0.007) and therefore the ratio of 25(OH)D:24,25(OH)2D was higher (mean 17.3 versus 11.1; p = 0.001). In those patients with active disease who achieved remission, there was a mean increase in 25(OH)D of 32.3 nmol/l (i.e. to a leve...Continue Reading

References

Oct 16, 1999·The Journal of Clinical Endocrinology and Metabolism·A VermeulenJ M Kaufman
Oct 15, 2003·The Journal of Clinical Endocrinology and Metabolism·Greet Van den BergheRoger Bouillon
May 25, 2010·Alimentary Pharmacology & Therapeutics·S P JørgensenJ F Dahlerup
Jul 16, 2010·Analytical and Bioanalytical Chemistry·Shujing DingDietrich A Volmer
Dec 3, 2010·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation (ECCO)
Mar 19, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Camille E PoweIshir Bhan
Apr 30, 2011·JPEN. Journal of Parenteral and Enteral Nutrition·Alex UlitskyMazen Issa
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society
Feb 14, 2013·Journal of Crohn's & Colitis·Søren Peter JørgensenJens Frederik Dahlerup
Nov 22, 2013·The New England Journal of Medicine·Camille E PoweRavi Thadhani
Jun 28, 2018·The Journal of Clinical Endocrinology and Metabolism·Josephine Lund-NielsenBørge G Nordestgaard

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