Vitamin D Modulates Hematological Parameters and Cell Migration into Peritoneal and Pulmonary Cavities in Alloxan-Diabetic Mice

BioMed Research International
Leonardo M BellaJoilson O Martins

Abstract

Background/Aims. The effects of cholecalciferol supplementation on the course of diabetes in humans and animals need to be better understood. Therefore, this study investigated the effect of short-term cholecalciferol supplementation on biochemical and hematological parameters in mice. Methods. Male diabetic (alloxan, 60 mg/kg i.v., 10 days) and nondiabetic mice were supplemented with cholecalciferol for seven days. The following parameters were determined: serum levels of 25-hydroxyvitamin D, phosphorus, calcium, urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, red blood cell count, white blood cell count (WBC), hematocrit, hemoglobin, differential cell counts of peritoneal lavage (PeL), and bronchoalveolar lavage (BAL) fluids and morphological analysis of lung, kidney, and liver tissues. Results. Relative to controls, cholecalciferol supplementation increased serum levels of 25-hydroxyvitamin D, calcium, hemoglobin, hematocrit, and red blood cell counts and decreased leukocyte cell counts of PeL and BAL fluids in diabetic mice. Diabetic mice that were not treated with cholecalciferol had lower serum calcium and albumin levels and hemoglobin, WBC, and mononuclear blood cell counts a...Continue Reading

References

Mar 29, 2003·Diabetes Care·Merlin C ThomasGeorge Jerums
Apr 23, 2004·Acta Diabetologica·S Thomas, M Rampersad
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Giovanni F M StrippoliFrancesco P Schena
Jan 18, 2005·Calcified Tissue International·J Del Pino-MontesJ M Quesada
Apr 27, 2005·Diabetes/metabolism Research and Reviews·Khanh vinh quoc LuongDung Ngoc Pham Nguyen
Jan 20, 2006·Obesity Research·Edward L MelansonMichael B Zemel
Mar 21, 2007·Toxicon : Official Journal of the International Society on Toxinology·Fernanda P B NunesMaria Cristina C Sousa-e-Silva
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Nov 24, 2007·Biochimica Et Biophysica Acta·Sangeeta AdakMaitree Bhattacharyya
Dec 17, 2008·The Diabetes Educator·Sue PenckoferMary Ann Emanuele
Jul 1, 2009·Diabetes Care·Uzma Mehdi, Robert D Toto
Oct 21, 2009·Annals of Hematology·John J SimScott A Rasgon
Dec 8, 2009·Endocrinology·Shuanhu ZhouJulie Glowacki
Nov 5, 2010·The American Journal of Clinical Nutrition·Heather M Ochs-BalcomJo L Freudenheim
May 4, 2011·World Journal of Diabetes·Pradeep Kumar Dabla
Jun 23, 2011·Therapeutic Advances in Gastroenterology·Terri D Johnson-Wimbley, David Y Graham
Dec 21, 2011·Journal of Proteome Research·Hemangi S BhonsleMahesh J Kulkarni
Mar 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrea IcardiMario Cozzolino
Jun 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gilberto Ornelas OliveiraAna Angélica Henrique Fernandes
Apr 30, 2014·Hormones : International Journal of Endocrinology and Metabolism·Chittari Venkata Harinarayan
Oct 18, 2014·World Journal of Clinical Cases·George LiamisMoses Elisaf

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Citations

Sep 15, 2018·Experimental and Therapeutic Medicine·Li FengDaping Deng

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Methods Mentioned

BETA
bronchoalveolar lavage
ELISA
lavage
glycosylation

Software Mentioned

NIS
Elements AR
GraphPad Prism

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