Abstract
Background/Aims. The effects of cholecalciferol supplementation on the course of diabetes in humans and animals need to be better understood. Therefore, this study investigated the effect of short-term cholecalciferol supplementation on biochemical and hematological parameters in mice. Methods. Male diabetic (alloxan, 60 mg/kg i.v., 10 days) and nondiabetic mice were supplemented with cholecalciferol for seven days. The following parameters were determined: serum levels of 25-hydroxyvitamin D, phosphorus, calcium, urea, creatinine, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, red blood cell count, white blood cell count (WBC), hematocrit, hemoglobin, differential cell counts of peritoneal lavage (PeL), and bronchoalveolar lavage (BAL) fluids and morphological analysis of lung, kidney, and liver tissues. Results. Relative to controls, cholecalciferol supplementation increased serum levels of 25-hydroxyvitamin D, calcium, hemoglobin, hematocrit, and red blood cell counts and decreased leukocyte cell counts of PeL and BAL fluids in diabetic mice. Diabetic mice that were not treated with cholecalciferol had lower serum calcium and albumin levels and hemoglobin, WBC, and mononuclear blood cell counts a...Continue Reading
References
Dec 25, 2002·Journal of Ethnopharmacology·Ajit KarN G Bandyopadhyay
Mar 29, 2003·Diabetes Care·Merlin C ThomasGeorge Jerums
Apr 23, 2004·Acta Diabetologica·S Thomas, M Rampersad
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Giovanni F M StrippoliFrancesco P Schena
Dec 9, 2004·The American Journal of Clinical Nutrition·Michael F Holick
Jan 18, 2005·Calcified Tissue International·J Del Pino-MontesJ M Quesada
Apr 27, 2005·Diabetes/metabolism Research and Reviews·Khanh vinh quoc LuongDung Ngoc Pham Nguyen
Jan 20, 2006·Obesity Research·Edward L MelansonMichael B Zemel
Mar 21, 2007·Toxicon : Official Journal of the International Society on Toxinology·Fernanda P B NunesMaria Cristina C Sousa-e-Silva
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Nov 24, 2007·Biochimica Et Biophysica Acta·Sangeeta AdakMaitree Bhattacharyya
Dec 17, 2008·The Diabetes Educator·Sue PenckoferMary Ann Emanuele
Jul 1, 2009·Diabetes Care·Uzma Mehdi, Robert D Toto
Oct 21, 2009·Annals of Hematology·John J SimScott A Rasgon
Dec 8, 2009·Endocrinology·Shuanhu ZhouJulie Glowacki
Nov 5, 2010·The American Journal of Clinical Nutrition·Heather M Ochs-BalcomJo L Freudenheim
May 4, 2011·World Journal of Diabetes·Pradeep Kumar Dabla
Jun 23, 2011·Therapeutic Advances in Gastroenterology·Terri D Johnson-Wimbley, David Y Graham
Sep 29, 2011·Endocrinology·John P DriverDavid V Serreze
Dec 21, 2011·Journal of Proteome Research·Hemangi S BhonsleMahesh J Kulkarni
Jan 10, 2012·The British Journal of Nutrition·Naijil GeorgeC S Paulose
Mar 15, 2012·Diabetes·Fernando SpillerFernando Q Cunha
Mar 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrea IcardiMario Cozzolino
Jun 19, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gilberto Ornelas OliveiraAna Angélica Henrique Fernandes
Feb 20, 2014·Diabetes·Tatiana TakiishiChantal Mathieu
Apr 30, 2014·Hormones : International Journal of Endocrinology and Metabolism·Chittari Venkata Harinarayan
Jul 26, 2014·Diabetes Care·Barbara Menart-HoutermansUNKNOWN German Diabetes Study Group
Oct 18, 2014·World Journal of Clinical Cases·George LiamisMoses Elisaf