PMID: 3768201Jan 1, 1986Paper

Vitamin D, parathyroid, and thymus gland influences on seasonal variations in renal electrolyte excretion

Bone
D Desroches, C R Martin

Abstract

Effects of the thymus gland and vitamin D and other calcium-regulating hormones on electrolyte balance were investigated. In studies conducted over 3 successive years male hooded rats excreted more chloride (Cl) and less inorganic phosphate (P) in April-August (summer) than in November-March (winter) when subjected to sham operation (SHAM) or to the surgical procedures described herein and exposed to natural sunlight in temperature- and humidity-controlled rooms. Parathyroidectomy, combined with sham thymectomy (PX), thymectomy (PX-TMX), thyroidectomy-sham thymectomy (TPX), or thyroidectomy-thymectomy (TPX-TMX), significantly increased Cl excretion during both seasons. The same surgical procedures also reduced P excretion in the winter. However, PX and PX-TMX lowered the P values only slightly in summer, and the effects were reversed by thyroid ablation. Thymectomy (TMX), alone or in combination with PX or TPX, increased Cl excretion during the summer, but it did not affect the outputs of winter animals with intact thyroid or parathyroid glands. Vitamin D3 (400 IU) injected three times weekly for 3 weeks increased the Cl excretion of all surgical groups during the winter. In the summer, it increased the Cl excretion of SHAM onl...Continue Reading

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