Vitamin D polygenic score is associated with neuroticism and the general psychopathology factor.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Reut AvinunSalomon Israel

Abstract

Vitamin D, used here to refer to both 25-hydroxyvitamin D, the main circulating form of the vitamin, and 1,25-hydroxyvitamin D, the biologically active form, has been shown to influence brain development and function. Consistent with these findings, low levels of vitamin D have been implicated in various mental disorders, including depression, schizophrenia, and autism. Recently, a shared variance across multiple categories of mental health disorders has been identified and shown to be genetically influenced. This shared variance, thought to represent a general risk for psychopathology, has been termed the p factor. Individuals with high p factor scores are characterized by high neuroticism and low agreeableness and conscientiousness. Here, we investigated the links between vitamin D polygenic scores - derived from the latest genome-wide association study of circulating vitamin D (25-hydroxyvitamin D) levels - the Big Five personality traits (neuroticism, agreeableness, conscientiousness, openness-to-experience, and extraversion), and the p factor, in a sample of 522 (278 women, mean age 20 ± 1 years) non-Hispanic Caucasians. Vitamin D polygenic scores were significantly and negatively associated with neuroticism and the p fact...Continue Reading

Related Concepts

Related Feeds

Autism

Autism spectrum disorder is associated with challenges with social skills, repetitive behaviors, and often accompanied by sensory sensitivities and medical issues. Here is the latest research on autism.

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
Oleg TsuprykovBerthold Hocher
The Proceedings of the Nutrition Society
Ilkka Laaksi
Current Opinion in Clinical Nutrition and Metabolic Care
Arash Hossein-nezhad, Michael F Holick
© 2021 Meta ULC. All rights reserved