Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice.

Scientific Reports
Satoshi NakamuraTakeshi Miyamoto

Abstract

Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle atrophy following limb immobilization than controls. Moreover, immobilization-induced muscle atrophy was worse in neural crest-specific than in skeletal muscle-specific VDR-deficient mice. Tnfα expression was significantly higher in immobilized muscle of VDR-deficient relative to control mice, and was significantly elevated in neural crest-specific but not muscle-specific VDR-deficient mice. Furthermore, muscle atrophy induced by limb immobilization in low vitamin D mice was significantly inhibited in Tnfα-deficient mice. We conclude that vitamin D antagonizes immobilization-induced muscle atrophy via VDR expressed in neural crest-derived cells.

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Citations

Apr 4, 2021·Nutrients·Mateusz Jakub KarniaJan Jacek Kaczor
May 6, 2021·Journal of Cachexia, Sarcopenia and Muscle·Wen-Qing XieYu-Sheng Li
May 21, 2021·Journal of Applied Physiology·Matthew J FogartyGary C Sieck
Aug 15, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lin YinGuanhua Du

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