Vitamin D Receptor Ablation and Vitamin D Deficiency Result in Reduced Grip Strength, Altered Muscle Fibers, and Increased Myostatin in Mice

Calcified Tissue International
Christian M GirgisJenny E Gunton

Abstract

Vitamin D deficiency is associated with muscle weakness, pain, and atrophy. Serum vitamin D predicts muscle strength and age-related muscle changes. However, precise mechanisms by which vitamin D affects skeletal muscle are unclear. To address this question, this study characterizes the muscle phenotype and gene expression of mice with deletion of vitamin D receptor (VDRKO) or diet-induced vitamin D deficiency. VDRKO and vitamin D-deficient mice had significantly weaker grip strength than their controls. Weakness progressed with age and duration of vitamin D deficiency, respectively. Histological assessment showed that VDRKO mice had muscle fibers that were significantly smaller in size and displayed hyper-nuclearity. Real-time PCR also indicated muscle developmental changes in VDRKO mice with dysregulation of myogenic regulatory factors (MRFs) and increased myostatin in quadriceps muscle (>2-fold). Vitamin D-deficient mice also showed increases in myostatin and the atrophy marker E3-ubiqutin ligase MuRF1. As a potential explanation for grip strength weakness, both groups of mice had down-regulation of genes encoding calcium-handling and sarco-endoplasmic reticulum calcium transport ATPase (Serca) channels. This is the first re...Continue Reading

References

Nov 1, 1979·The Journal of Clinical Investigation·D PleasureD B Goodman
Mar 1, 1978·Kidney International·J S Rodman, T Baker
May 16, 2001·The Histochemical Journal·H A BischoffW Dick
Dec 13, 2003·The Journal of Clinical Endocrinology and Metabolism·Marjolein VisserUNKNOWN Longitudinal Aging Study Amsterdam
Feb 19, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H A Bischoff-FerrariW Dick
Jul 28, 2004·Brain Research Bulletin·Allan V KalueffPentti Tuohimaa
Feb 9, 2006·Brain Research Bulletin·Thomas H J BurneAlan Mackay-Sim
Jan 29, 2008·Journal of Molecular Biology·Suguru KoyamaHiroyuki Sorimachi
May 12, 2009·The Journal of Steroid Biochemistry and Molecular Biology·Anna MinasyanPentti Tuohimaa
Jun 3, 2010·Archives of Biochemistry and Biophysics·Laurie Schubert, Hector F DeLuca
Jul 16, 2010·The Journal of Clinical Endocrinology and Metabolism·K A WardM Z Mughal
Dec 31, 2010·Endocrinology·Yongji Wang, Hector F DeLuca
Jan 14, 2011·The American Journal of Clinical Nutrition·Ghattu V KrishnaveniCaroline H D Fall
Jun 15, 2011·Molecular and Cellular Endocrinology·Ricardo L Boland
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah E TaguePeter G Smith
Jun 1, 2012·American Journal of Physiology. Cell Physiology·Ratchakrit SrikueaKaryn A Esser
Jul 18, 2012·The Journal of Clinical Endocrinology and Metabolism·Pawel SzulcLorenz C Hofbauer
Nov 22, 2012·Endocrine Reviews·Christian M GirgisJenny E Gunton
Feb 5, 2013·The Journal of Clinical Investigation·Katsuhiko FunaiClay F Semenkovich
Nov 22, 2013·Clinical Endocrinology·Christian M GirgisJenny E Gunton
Mar 19, 2014·Current Osteoporosis Reports·Christian M GirgisDouglas J Digirolamo
Mar 26, 2014·Journal of Cellular Physiology·Nancy MokbelLowenna J Holt
Oct 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Mathis Grossmann

❮ Previous
Next ❯

Citations

Aug 17, 2016·Biochemical and Biophysical Research Communications·Hye-Joo Kwon
Oct 26, 2016·Journal of Photochemistry and Photobiology. B, Biology·Daigo MoritaNaoki Ishiguro
Mar 4, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Carla Domingues-FariaStéphane Walrand
May 23, 2018·The Journal of Clinical Endocrinology and Metabolism·Rada Faris Al-JwadiHenrik Thybo Christesen
Apr 17, 2019·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Sara PooyanKhadijeh Mirzaei
Jun 18, 2019·Nutrition Research Reviews·Karina Romeu MontenegroPhilip Newsholme
Jun 22, 2019·Journal of Cachexia, Sarcopenia and Muscle·Christian M GirgisJenny E Gunton
Jul 18, 2019·Calcified Tissue International·Christian M Girgis
Jan 16, 2020·American Journal of Physiology. Cell Physiology·Stephen P AshcroftAndrew Philp
Feb 6, 2020·Journal of Cachexia, Sarcopenia and Muscle·Aolin YangDifei Wang
Mar 12, 2016·Journal of Applied Physiology·Andrew D RayPamela A Hershberger
Jun 8, 2018·International Journal of Molecular Sciences·Chiara RiccaFrancesca Silvagno
Mar 14, 2018·Archives of Osteoporosis·Kahyun KimGoo Hyun Baek
Jan 1, 2018·Nuclear Receptor Research·Danika BakkeJun Sun
Oct 11, 2020·Cell Biochemistry and Function·Shelby E Bollen, Philip J Atherton
Nov 11, 2019·The Journal of Steroid Biochemistry and Molecular Biology·Ramesh GogulothuAyesha Ismail
Mar 7, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Emma L WatsonAlice C Smith
Mar 12, 2021·Hemodialysis International·Barbara Perez Vogt, Jacqueline Costa Teixeira Caramori
Apr 14, 2021·Scientific Reports·Satoshi OchiaiShiro Imagama
May 1, 2021·Nutrients·Małgorzata Kupisz-UrbańskaEwa Marcinowska-Suchowierska
May 21, 2021·Journal of Applied Physiology·Matthew J FogartyGary C Sieck
Jul 7, 2021·Alimentary Pharmacology & Therapeutics·Jordan J McGingGordon W Moran
Aug 6, 2021·Journal of Clinical Laboratory Analysis·Jun-Il YooMin-Chul Cho
Sep 25, 2021·Physiological Reports·Yoshihiro TakadaSusumu Sakata

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.