Vitamin D Receptor Activation in Liver Macrophages Protects Against Hepatic Endoplasmic Reticulum Stress in Mice.

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Ying ZhouDavid D Moore

Abstract

Hepatic endoplasmic reticulum (ER) stress, whether triggered by intrinsic or extrinsic factors, can be resolved by the unfolded protein response (UPR). Sustained UPR activation leads to cell death and inflammatory response and contributes to liver disease progression. Hepatic tissue macrophages are key players in orchestrating liver inflammation, and ER stress can enhance macrophage activation. However, it is not well defined how the interplay between ER stress and inflammation is regulated during hepatic stress response. Here we demonstrate that vitamin D receptor (VDR) activation mitigates hepatic ER stress response, whereas VDR knockout mice undergo persistent UPR activation and apoptosis in response to chemical ER stress inducer. Moreover, VDR deficiency promotes hepatic macrophage infiltration and increases gene expression and systematic levels of proinflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor α. VDR expression is induced in hepatic macrophages by ER stress, and VDR plays a dual regulatory role in macrophages by protecting against ER stress and promoting anti-inflammatory polarization. Co-culture with VDR-activated bone marrow-derived macrophages suppresses UPR target genes in pri...Continue Reading

References

Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Apr 28, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shaikh Mizanoor RahmanJacob E Friedman
Jun 15, 2007·Nature Reviews. Molecular Cell Biology·David Ron, Peter Walter
Nov 28, 2007·Annual Review of Pathology·Jonathan H LinT S Benedict Yen
Jan 24, 2008·Nature Clinical Practice. Endocrinology & Metabolism·John S Adams, Martin Hewison
Apr 11, 2008·The American Journal of Clinical Nutrition·Michael F Holick, Tai C Chen
Jul 25, 2008·Nature·Kezhong Zhang, Randal J Kaufman
Aug 13, 2008·Endocrine Reviews·Roger BouillonMarie Demay
Dec 15, 2010·Journal of Hepatology·Harmeet Malhi, Randal J Kaufman
Mar 3, 2011·Nature Cell Biology·Ira Tabas, David Ron
Apr 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Navin R MahadevanMaurizio Zanetti
Aug 17, 2011·Reviews in Endocrine & Metabolic Disorders·John H White
Oct 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christian L RothKris V Kowdley
Feb 4, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong ZhangElena Goleva
May 9, 2012·Cell Metabolism·Suneng FuGökhan S Hotamisligil
Jul 4, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ilaria BarchettaMaria Gisella Cavallo
Aug 14, 2012·Trends in Molecular Medicine·Abhishek D GargPatrizia Agostinis
Feb 14, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Caroline S StokesFrank Lammert
May 15, 2013·The Journal of Biological Chemistry·Yunzi ChenYan Chun Li
Jan 15, 2014·Journal of Hepatology·Frank Tacke, Henning W Zimmermann
Mar 4, 2014·World Journal of Gastroenterology : WJG·Xue-Qun ZhangYou-Ming Li
Feb 26, 2016·Cellular & Molecular Immunology·Cynthia Ju, Frank Tacke
Jun 30, 2016·Molecular Endocrinology·Kang Ho KimDavid D Moore

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Citations

Jun 13, 2020·Archives of Toxicology·Qiuhua TanZhengquan Su
Nov 3, 2020·World Journal of Gastroenterology : WJG·Ying CaoLi Zhang
Feb 13, 2021·Frontiers in Immunology·Hunter BennettChristopher K Glass
Mar 12, 2021·Endocrine Reviews·Amir AjoolabadyJun Ren
Jul 29, 2021·Advanced Science·Sevgican DemirBilgen Ekim Üstünel
Jan 7, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christos TriantosAthanasia Mouzaki

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