Vitamin D receptor alleles and bone's response to physical activity

Calcified Tissue International
T L JärvinenP Kannus

Abstract

The objective of this prospective controlled study was to determine whether the osteogenic response of bone to mechanical loading is dependent on the vitamin D receptor (VDR) polymorphism. Thirty-five healthy premenopausal women took part in a progressive, high-impact exercise three times a week for a period of 18 months and 45 women served as nonexercising controls. The trainees were divided into three groups: bb (n = 12, 34%); Bb (n = 16, 46%); BB (n = 7, 20%) according to polymorphism at the gene encoding the VDR (BB representing subjects without the restriction enzyme BsmI sites on the two VDR gene alleles). Bone mineral content (BMC) and areal bone mineral density (BMD) were measured at the lumber spine, proximal femur, knee, calcaneus, and dominant distal radius before the beginning of the exercise regimen and at 12 and 18 months of training using dual-energy x-ray absorptiometry (DXA). As an indicator of the total osteogenic effect of the training, SigmaBMC was derived by summing up the BMC values of the loaded sites (i.e., the lower limb sites and the lumbar spine). The mean SigmaBMC increased 2.0% in the bb group, 3.0% in the Bb group, and 2.8% in the BB group (P = 0.184 for the intergroup difference), but only 0. 8% i...Continue Reading

Citations

Dec 28, 1999·Public Health Nutrition·F Branca
Feb 24, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D A Nelson, M L Bouxsein
Apr 7, 2004·Journal of Physiological Anthropology and Applied Human Science·Fumihiro OmasuYoshibumi Nakahara
May 8, 2004·Journal of Women's Health·Liv Berit AugestadW Dana Flanders
Apr 1, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F-Y WuC-C Lin
Nov 2, 2001·Medicine and Science in Sports and Exercise·K DelvauxR Lysens
Jun 19, 2001·Medicine and Science in Sports and Exercise·T RankinenC Bouchard
Jan 10, 2002·Medicine and Science in Sports and Exercise·Claudine BlanchetSylvie Dodin
Mar 21, 2009·Journal of Aging and Physical Activity·Paulo GentilRinaldo Wellerson Pereira
May 14, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jonathan A MitchellBabette S Zemel
Oct 23, 2002·Journal of Applied Physiology·Orie NakamuraKumpei Tokuyama

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