PMID: 11910656Mar 26, 2002Paper

Vitamin D receptor and estrogen receptor gene polymorphisms in postmenopausal Danish women: no relation to bone markers or serum lipoproteins

Climacteric : the Journal of the International Menopause Society
Y Z BaggerC Christiansen

Abstract

To investigate the polymorphisms of the vitamin D receptor (VDR) and estrogen receptor (ER) genes in relation to biochemical markers of bone turnover (serum osteocalcin and urinary collagen type I degradation products (CrossLaps), and to study ER genotypes in relation to serum lipoproteins, blood pressure, or changes in these parameters after 2 years of hormone replacement therapy (HRT) in 499 Danish postmenopausal women. The VDR gene polymorphisms were determined by means of the three restriction enzymes, i.e. BsmI, ApaI and TaqI, while the ER gene polymorphisms were determined by means of the PvuII and XbaI restriction enzymes. Serum osteocalcin, urinary CrossLaps and the lipoproteins were also assessed. Body mass index was recorded. The VDR or ER genotypes did not differ significantly with respect to age, age at menopause or body mass index. No significant effect of VDR or ER genotype on bone turnover was found. Furthermore, we were unable to find any relationship between ER genotype and lipoproteins or blood pressure at baseline, or changes in these parameters during HRT. A clinically significant relationship between VDR and ER genotypes and biochemical markers of bone turnover or serum lipoproteins could not be demonstrate...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·N A MorrisonJ A Eisman
Aug 1, 1992·Journal of the American College of Cardiology·J K WilliamsT B Clarkson
Jun 11, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·C W SlemendaC C Johnston
Apr 1, 1991·The Journal of Clinical Endocrinology and Metabolism·P J KellyJ A Eisman
Mar 2, 1989·The New England Journal of Medicine·E SeemanG Jerums
Sep 1, 1987·The Journal of Clinical Investigation·N A PocockS Eberl
Aug 1, 1980·European Journal of Clinical Investigation·C ChristiansenI Transbøl
Apr 14, 1983·The New England Journal of Medicine·P WahlB Rifkind
Jan 20, 1994·Nature·N A MorrisonJ A Eisman
Jun 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·P GarneroP D Delmas
Mar 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S KobayashiH Orimo
Oct 22, 1998·Metabolism: Clinical and Experimental·S VadlamudiH Barakat

❮ Previous
Next ❯

Citations

Sep 25, 2002·Maturitas·Hugo MaiaElsimar M Coutinho
Jun 1, 2006·Menopause : the Journal of the North American Menopause Society·Sandra SilvestriMaria Luisa Brandi
Jun 4, 2008·Pharmacogenomics·Francesco MassartMaria Luisa Brandi
Mar 23, 2007·Expert Opinion on Pharmacotherapy·Luigi GennariRanuccio Nuti
May 19, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Mohammadali BoroumandHamidreza Goodarzynejad
Mar 14, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Attila MolvarecIstván Karádi

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
R JofréF Valderrábano
Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
A C CatoU Fuhrmann
© 2022 Meta ULC. All rights reserved