Vitamin D receptor gene FokI, TaqI, BsmI, and ApaI polymorphisms and susceptibility to pulmonary tuberculosis: a meta-analysis

Genetics and Molecular Research : GMR
Young Ho Lee, G G Song

Abstract

The aim of this study was to determine whether vitamin D receptor (VDR) genetic polymorphisms are associated with the susceptibility to pulmonary tuberculosis (PTB). MEDLINE and Embase databases and manual literature searches were used. A meta-analysis was conducted on the associations between the VDR FokI, TaqI, BsmI, and ApaI polymorphisms and PTB susceptibility. A total of 16 studies comprising 3231 patients and 3670 controls met the study inclusion criteria, consisting of 14 studies on the VDR FokI polymorphism, 13 on the VDR TaqI polymorphism, 8 on the VDR BsmI polymorphism, and 5 on the VDR ApaI polymorphism. Meta-analysis of the VDR FokI polymorphism showed no association between PTB and the f allele of the VDR FokI polymorphism (long variant) in all subjects (OR = 1.070, 95%CI = 0.979-1.169, P = 0.134). In contrast, after stratification by ethnicity, meta-analysis indicated that the VDR FokI F allele (short variant) was associated with PTB risk in an East Asian population (OR = 1.507, 95%CI = 1.192-1.906, P = 0.001). Meta-analysis revealed no association between PTB susceptibility and the VDR TaqI t allele in all study subjects (OR = 0.986, 95%CI = 0.839-1.159, P = 0.866) or in individual ethnic populations. Furthermore...Continue Reading

Citations

Jul 8, 2017·Tropical Medicine & International Health : TM & IH·Hoang van TongChristian G Meyer
Oct 24, 2017·International Journal of Immunogenetics·M QrafliK Sadki
May 29, 2018·Journal of Internal Medicine·S BrighentiA R Martineau
Aug 31, 2020·International Journal of Mycobacteriology·Jalaledin GhanaviAli Akbar Velayati
Sep 1, 2018·Frontiers in Medicine·Murugesan HarishankarRamalingam Bethunaickan
Jan 5, 2018·The Pharmacogenomics Journal·Payman ShahabiMarie-Pierre Dubé
Sep 6, 2019·Oxidative Medicine and Cellular Longevity·Li CaiYeqing Tong
Jan 16, 2021·Nucleosides, Nucleotides & Nucleic Acids·Mohammad Ali MashhadiMahdiyeh Harati-Sadegh
Oct 28, 2016·Microbiology Spectrum·Vivek Naranbhai

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